GHK-Cu

GHK-Cu Research Peptide (Copper Tripeptide)
Lyophilized Format • ≥99% HPLC Purity • Ships in 1–2 Business Days • U.S. Warehouses

GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper, CAS 49557-75-7) is a naturally occurring copper-binding tripeptide first isolated from human plasma, supplied by Nextday Peptides for laboratory and analytical research applications. Composed of glycine, histidine, and lysine complexed with copper(II), GHK-Cu is one of the most extensively studied copper-peptide complexes in cellular biology research. Each vial is independently verified to ≥99% HPLC purity with a Certificate of Analysis available on request. For scientific research use only.

Compound Specifications

Why Research Laboratories Select GHK-Cu

GHK-Cu is among the most studied copper-peptide complexes in current cellular and molecular biology research. First isolated from human plasma by Pickart et al. in the 1970s, its strong affinity for copper(II) and ability to influence gene expression across multiple cellular pathways has made it a widely referenced research tool for laboratories investigating extracellular matrix biology, copper-dependent signaling, and cellular stress response models.

• Naturally occurring copper-binding tripeptide — first isolated from human plasma by Loren Pickart, Ph.D. in 1973
• Strong Cu²⁺ affinity — coordinates copper(II) via the Gly-His-Lys amino acid sequence
• Studied in preclinical models examining extracellular matrix remodeling, fibroblast activity, and collagen-associated signaling
• Referenced in gene expression research involving over 4,000 human genes in laboratory settings
• Appears as distinctive blue-green powder due to copper(II) complexation — visually distinguishable from non-copper peptides
• Lyophilized format ensures stability and reproducibility across experimental runs
• Batch and lot identifiers on all labeling for full laboratory documentation compliance

Research Background

GHK-Cu was first identified in human plasma in 1973 by Loren Pickart, Ph.D., who noted its role as a liver cell growth factor. Subsequent preclinical studies have examined its role in copper-dependent enzymatic activity, extracellular matrix signaling, fibroblast and keratinocyte response models, angiogenesis-associated markers, and transcriptional regulation of genes associated with cellular remodeling and stress response. Pickart’s research group has published extensively on GHK-Cu biology across more than 100 peer-reviewed publications. All information provided here is for educational and reference purposes only and does not constitute medical or clinical guidance.

Reference sources: PubChem — GHK-Cu (CID 73587) | Wikipedia — Copper Peptide GHK-Cu

Shipping & Fulfillment

• Ships from U.S. warehouses — Florida, North Carolina, and California
• Overnight and 2-day shipping available at checkout
• Same-day processing on orders placed before 3:30 PM ET
• Discreet packaging with full tracking provided
• Bulk research orders welcome — contact us for volume pricing

Storage & Handling

• Store lyophilized peptide at -20°C away from light and moisture
• After reconstitution store at 2–8°C and use promptly
• Note: GHK-Cu may have limited solubility in bacteriostatic water alone — researchers often begin reconstitution with a small volume of 0.6% acetic acid
• Avoid repeated freeze-thaw cycles to maintain integrity
• Handle using appropriate laboratory safety protocols for copper-peptide complexes
• Keep containers sealed when not in use

Frequently Asked Questions

For Research Use Only — Not for human or veterinary consumption • Not evaluated by the FDA • Supplied by Nextday Peptides for laboratory research applications only