CJC-1295 No DAC Research Peptide (Modified GRF 1-29)
Lyophilized Format • ≥99% HPLC Purity • Ships in 1–2 Business Days • U.S. Warehouses
CJC-1295 No DAC (Modified GRF 1-29) is a synthetic 29 amino acid GHRH analog supplied by Nextday Peptides for laboratory and analytical research applications. Also known as CJC-1295 without DAC, this modified peptide incorporates sequence changes that enhance resistance to DPP-IV enzymatic degradation compared to native GHRH, while producing shorter-acting pulsatile receptor activation in experimental models. Each vial is independently verified to ≥99% HPLC purity with a Certificate of Analysis available on request. For scientific research use only.
Compound Specifications
| Compound Name | CJC-1295 No DAC / Modified GRF (1-29) / Mod GRF 1-29 |
| Amino Acids | 29 |
| Receptor Target | GHRH Receptor (GHRHR) |
| Molecular Formula | C₁₅₂H₂₅₂N₄₄O₄₂ |
| Form | Lyophilized powder |
| Appearance | White to off-white powder |
| Purity | ≥99% (HPLC verified) |
| Storage | -20°C lyophilized; 2–8°C after reconstitution |
| CAS Number | 446036-97-1 |
| Also Known As | Mod GRF 1-29, Modified GRF 1-29, CJC-1295 without DAC |
Why Research Laboratories Select CJC-1295 No DAC
CJC-1295 No DAC is one of the most studied modified GHRH analogs in current endocrine research. Its 29 amino acid sequence incorporates modifications that enhance resistance to DPP-IV enzymatic degradation compared to native GHRH, while the absence of the Drug Affinity Complex produces shorter-acting pulsatile receptor activation in experimental models. This makes it a valuable tool for laboratories investigating pulsatile GH secretagogue dynamics and GHRH receptor pharmacology.
- Modified GRF 1-29 — enhanced DPP-IV resistance compared to native Sermorelin/GHRH
- Shorter acting than DAC version — studies pulsatile GHRH receptor activation patterns
- Activates cAMP/PKA signaling pathways via GHRH receptors on pituitary somatotrophs
- Frequently studied in GHRH receptor pharmacology and comparative secretagogue research
- Lyophilized format ensures stability and reproducibility across experimental runs
- Batch and lot identifiers on all labeling for full laboratory documentation compliance
Research Background
CJC-1295 No DAC (Modified GRF 1-29) is a synthetic GHRH analog that has been referenced in scientific literature on pituitary signaling and growth hormone axis biology. Teichman et al. (2006) published findings on GHRH analog pharmacokinetics in the Journal of Clinical Endocrinology and Metabolism. Alba et al. (2006) examined GHRH analog effects in knockout mouse models, published in the American Journal of Physiology. All information provided here is for educational and reference purposes only and does not constitute medical or clinical guidance.
Reference sources: PubChem — CJC-1295
Shipping & Fulfillment
- Ships from U.S. warehouses — Florida, North Carolina, and California
- Overnight and 2-day shipping available at checkout
- Same-day processing on orders placed before cutoff
- Discreet packaging with full tracking provided
- Bulk research orders welcome — contact us for volume pricing
Storage & Handling
- Store lyophilized peptide at -20°C away from light and moisture
- After reconstitution, store at 2–8°C and use promptly
- Avoid repeated freeze-thaw cycles to maintain integrity
- Handle using appropriate laboratory safety protocols
- Keep containers sealed when not in use
Frequently Asked Questions
What is CJC-1295 No DAC?
CJC-1295 No DAC (Modified GRF 1-29) is a synthetic 29 amino acid GHRH analog with modifications enhancing enzymatic stability. Without the Drug Affinity Complex it produces shorter-acting pulsatile GHRH receptor activation in experimental models. Supplied strictly for scientific, analytical, and in-vitro laboratory research use only.
What is the difference between CJC-1295 with DAC and without DAC?
The DAC version binds reversibly to albumin in experimental systems, significantly extending its half-life for sustained receptor activation studies. CJC-1295 No DAC has a shorter half-life of approximately 30 minutes to 2 hours in research models, making it useful for studying pulsatile GH secretagogue dynamics that more closely mimic natural episodic signaling patterns.
How does CJC-1295 No DAC differ from Sermorelin?
Both are 29 amino acid GHRH analogs derived from the same endogenous sequence. CJC-1295 No DAC incorporates additional amino acid modifications specifically designed to enhance resistance to DPP-IV enzymatic degradation, giving it improved stability compared to Sermorelin in experimental settings.
What purity is your CJC-1295 No DAC?
Every batch is independently verified to ≥99% HPLC purity. A Certificate of Analysis is available for each lot.
How fast does Nextday Peptides ship?
We ship from U.S. warehouses in Florida, North Carolina, and California. Overnight and 2-day shipping options are available. Most orders process same day.
Are bulk orders available?
Yes. We accommodate bulk research orders. Contact us directly for volume pricing and availability.
Is this product approved for medical use?
No. This product is for laboratory research use only. It is not approved for human or veterinary use, and is not intended for diagnostic, therapeutic, or clinical applications.
What other compounds does Nextday Peptides carry?
We stock a full range of research peptides including Sermorelin, Ipamorelin, BPC-157, and TB-500. View our full research compounds catalog.
For Research Use Only — Not for human or veterinary consumption • Not evaluated by the FDA • Supplied by Nextday Peptides for laboratory research applications only
