Sermorelin Research Peptide (GHRH 1-29)
Lyophilized Format • ≥99% HPLC Purity • Ships in 1–2 Business Days • U.S. Warehouses
Sermorelin (GHRH 1-29) is a synthetic 29 amino acid peptide comprising the shortest fully functional fragment of endogenous human Growth Hormone-Releasing Hormone (GHRH), supplied by Nextday Peptides for laboratory and analytical research applications. As a GHRH receptor agonist in experimental models, Sermorelin is one of the most established reference compounds for investigating pituitary signaling pathways and endocrine axis biology. Each vial is independently verified to ≥99% HPLC purity with a Certificate of Analysis available on request. For scientific research use only.
Compound Specifications
| Compound Name | Sermorelin / GHRH (1-29) / GRF 1-29 |
| Peptide Sequence | Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂ |
| Amino Acids | 29 |
| Receptor Target | GHRH Receptor (GHRHR) on pituitary somatotrophs |
| Molecular Formula | C₁₄₉H₂₄₆N₄₄O₄₂S |
| Molecular Weight | 3,357.9 g/mol |
| Form | Lyophilized powder |
| Appearance | White to off-white powder |
| Purity | ≥99% (HPLC verified) |
| Storage | -20°C lyophilized; 2–8°C after reconstitution |
| CAS Number | 86168-78-7 |
| Synonym | GHRH (1-29), GRF 1-29 |
Why Research Laboratories Select Sermorelin
Sermorelin is the shortest fully functional synthetic fragment of human GHRH, making it one of the most precise and well-characterized GHRH receptor agonists available for laboratory research. Its defined 29 amino acid sequence and established receptor binding profile make it a valuable reference compound for laboratories investigating GHRH receptor activation, pituitary somatotroph signaling, and endocrine axis biology in preclinical models.
- 29 amino acid synthetic GHRH fragment — shortest fully functional fragment of endogenous GHRH
- GHRH receptor agonist — activates cAMP and MAPK signaling pathways in experimental pituitary systems
- Extensively studied in preclinical models for GHRH pathway characterization
- Useful reference compound for comparative studies alongside other GH secretagogues including GHRPs
- Lyophilized format ensures stability and reproducibility across experimental runs
- Batch and lot identifiers on all labeling for full laboratory documentation compliance
Research Background
Sermorelin was originally characterized as a diagnostic research tool and represents the first 29 amino acids of endogenous human GHRH. In vitro studies using anterior pituitary cultures have examined its dose-dependent effects on intracellular cAMP signaling in somatotroph cells. It has been referenced extensively in scientific literature on GHRH receptor pharmacology, pituitary signaling, and endocrine axis biology. All information provided here is for educational and reference purposes only and does not constitute medical or clinical guidance.
Reference sources: PubChem — Sermorelin
Shipping & Fulfillment
- Ships from U.S. warehouses — Florida, North Carolina, and California
- Overnight and 2-day shipping available at checkout
- Same-day processing on orders placed before cutoff
- Discreet packaging with full tracking provided
- Bulk research orders welcome — contact us for volume pricing
Storage & Handling
- Store lyophilized peptide at -20°C away from light and moisture
- After reconstitution, store at 2–8°C and use promptly
- Avoid repeated freeze-thaw cycles to maintain integrity
- Handle using appropriate laboratory safety protocols
- Keep containers sealed when not in use
Frequently Asked Questions
What is Sermorelin?
Sermorelin (GHRH 1-29) is a synthetic 29 amino acid peptide comprising the shortest fully functional fragment of human Growth Hormone-Releasing Hormone. It is a GHRH receptor agonist studied in laboratory research settings. Supplied strictly for scientific, analytical, and in-vitro laboratory research use only.
How does Sermorelin differ from Ipamorelin?
Sermorelin acts on GHRH receptors (GHRHRs) on pituitary somatotroph cells, initiating GH release through cAMP signaling. Ipamorelin acts on ghrelin receptors (GHS-R1a) through a separate Gq/PLC pathway. They target different receptors and are studied as complementary tools in GH secretagogue research.
What purity is your Sermorelin?
Every batch is independently verified to ≥99% HPLC purity. A Certificate of Analysis is available for each lot.
How fast does Nextday Peptides ship?
We ship from U.S. warehouses in Florida, North Carolina, and California. Overnight and 2-day shipping options are available. Most orders process same day.
Are bulk orders available?
Yes. We accommodate bulk research orders. Contact us directly for volume pricing and availability.
Is this product approved for medical use?
No. This product is for laboratory research use only. It is not approved for human or veterinary use, and is not intended for diagnostic, therapeutic, or clinical applications.
What other compounds does Nextday Peptides carry?
We stock a full range of research peptides including Ipamorelin, BPC-157, TB-500, and Retatrutide GLP-3. View our full research compounds catalog.
For Research Use Only — Not for human or veterinary consumption • Not evaluated by the FDA • Supplied by Nextday Peptides for laboratory research applications only
