TB-500 Research Peptide (Thymosin Beta-4)
Lyophilized Format • ≥99% HPLC Purity • Ships in 1–2 Business Days • U.S. Warehouses
TB-500 (Thymosin Beta-4) is a synthetic 43 amino acid peptide corresponding to the full sequence of the naturally occurring Thymosin Beta-4 protein, originally derived from thymus tissue. Supplied by Nextday Peptides for laboratory and analytical research applications, each vial is independently verified to ≥99% HPLC purity with a Certificate of Analysis available on request. For scientific research use only.
Compound Specifications
| Compound Name | TB-500 / Thymosin Beta-4 / Tβ4 |
| Amino Acids | 43 |
| Molecular Formula | C₂₁₂H₃₅₀N₅₆O₇₈S |
| Molecular Weight | 4,963.4 g/mol |
| PubChem CID | 16132341 |
| Form | Lyophilized powder |
| Appearance | White to off-white powder |
| Purity | ≥99% (HPLC verified) |
| Storage | -20°C lyophilized; 2–8°C after reconstitution |
| CAS Number | 77591-33-4 |
Why Research Laboratories Select TB-500
TB-500 is one of the most extensively studied actin-binding peptides in current laboratory research. As a synthetic equivalent of the naturally occurring Thymosin Beta-4 protein — present in virtually all human and animal cells — it is a valuable reference compound for laboratories investigating cytoskeletal organization, actin dynamics, cell migration mechanisms, and angiogenic signaling in preclinical settings.
- 43 amino acid synthetic peptide corresponding to full Thymosin Beta-4 sequence
- Key actin-binding peptide — studied for its role in G-actin sequestration and F-actin dynamics
- Referenced in peer-reviewed literature on cytoskeletal biology and cell migration research
- Active site LKKTETQ sequence studied for actin binding and cellular motility research
- Studied alongside BPC-157 in comparative tissue biology research models
- Lyophilized format ensures stability and reproducibility across experimental runs
- Batch and lot identifiers on all labeling for full laboratory documentation compliance
Research Background
TB-500 (Thymosin Beta-4) has been referenced in scientific literature since the discovery of thymosins by Goldstein et al. in the 1960s. Preclinical studies in rodent and cell-based models have examined its role in actin monomer sequestration, cytoskeletal remodeling, endothelial cell organization, and angiogenic signaling pathways. All information provided here is for educational and reference purposes only and does not constitute medical or clinical guidance.
Reference sources: PubChem — TB-500 (CID 16132341)
Shipping & Fulfillment
- Ships from U.S. warehouses — Florida, North Carolina, and California
- Overnight and 2-day shipping available at checkout
- Same-day processing on orders placed before cutoff
- Discreet packaging with full tracking provided
- Bulk research orders welcome — contact us for volume pricing
Storage & Handling
- Store lyophilized peptide at -20°C away from light and moisture
- After reconstitution, store at 2–8°C and use promptly
- Avoid repeated freeze-thaw cycles to maintain integrity
- Handle using appropriate laboratory safety protocols
- Keep containers sealed when not in use
Frequently Asked Questions
What is TB-500?
TB-500 is a synthetic 43 amino acid peptide corresponding to the full sequence of Thymosin Beta-4, an actin-binding protein naturally present in virtually all human and animal cells. It is supplied strictly for scientific, analytical, and in-vitro laboratory research use only.
What is the active site of TB-500?
The LKKTETQ sequence (positions 17-23) is the active actin-binding domain within Thymosin Beta-4 that is the subject of significant research into cytoskeletal regulation and cell migration mechanisms in laboratory settings.
How does TB-500 differ from BPC-157?
TB-500 is a 43 amino acid peptide derived from Thymosin Beta-4, primarily studied in the context of actin binding and cytoskeletal research. BPC-157 is a 15 amino acid pentadecapeptide derived from gastric juice protein. Both are studied in preclinical tissue biology research but through different molecular mechanisms.
What purity is your TB-500?
Every batch is independently verified to ≥99% HPLC purity. A Certificate of Analysis is available for each lot.
How fast does Nextday Peptides ship?
We ship from U.S. warehouses in Florida, North Carolina, and California. Overnight and 2-day shipping options are available. Most orders process same day.
Are bulk orders available?
Yes. We accommodate bulk research orders. Contact us directly for volume pricing and availability.
Is this product approved for medical use?
No. This product is for laboratory research use only. It is not approved for human or veterinary use, and is not intended for diagnostic, therapeutic, or clinical applications.
What other compounds does Nextday Peptides carry?
We stock a full range of research peptides including BPC-157, Retatrutide GLP-3, Semaglutide GLP-1, and MOTS-C. View our full research compounds catalog.
For Research Use Only — Not for human or veterinary consumption • Not evaluated by the FDA • Supplied by Nextday Peptides for laboratory research applications only
