MOTS-C Research Peptide
Lyophilized Format • ≥99% HPLC Purity • Ships in 1–2 Business Days • U.S. Warehouses
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16 amino acid mitochondrial-derived peptide (MDP) supplied by Nextday Peptides for laboratory and analytical research applications. First formally characterized in a landmark 2015 study published in Cell Metabolism, MOTS-C is encoded within the mitochondrial 12S rRNA gene. Each vial is independently verified to ≥99% HPLC purity with a Certificate of Analysis available on request. For scientific research use only.
Compound Specifications
| Compound Name | MOTS-C / Mitochondrial Open Reading Frame of the 12S rRNA-c |
| Amino Acid Sequence | MRWQEMGYIFYPRKLR |
| Amino Acids | 16 |
| Molecular Weight | 2,174.6 g/mol |
| Form | Lyophilized powder |
| Appearance | White to off-white powder |
| Purity | ≥99% (HPLC verified) |
| Storage | -20°C lyophilized; 2–8°C after reconstitution |
| CAS Number | 1627580-64-6 |
| Origin | Mitochondrial genome — 12S rRNA gene |
Why Research Laboratories Select MOTS-C
MOTS-C is among the most studied mitochondrial-derived peptides in current metabolic and cellular biology research. As a peptide encoded by mitochondrial DNA but translated in the cytoplasm, it represents a unique class of signaling molecules that have drawn significant scientific interest since its initial characterization in 2015.
- Unique mitochondrial-derived peptide — encoded by mtDNA, translated in the cytoplasm
- 16 amino acid sequence highly conserved across 14 species including humans and mice
- Studied in the context of AMPK pathway activation in preclinical metabolic research models
- Referenced in peer-reviewed literature including Cell Metabolism, Scientific Reports, and Geroscience
- Relevant to laboratory research on mitochondrial signaling, cellular stress response, and metabolic pathways
- Lyophilized format ensures stability and reproducibility across experimental runs
- Batch and lot identifiers on all labeling for full laboratory documentation compliance
Research Background
MOTS-C was first formally characterized in 2015 by Lee et al. in Cell Metabolism, establishing it as a functional peptide encoded within the mitochondrial genome. Subsequent preclinical studies have examined its role in mitochondrial-nuclear communication, AMPK pathway interactions, and metabolic signaling in rodent models. MOTS-C has been noted as the first mitochondrial-encoded peptide to enter clinical trials, according to published literature. All information provided here is for educational and reference purposes only and does not constitute medical or clinical guidance.
Reference sources: PubChem — MOTS-C | NIH — MOTS-C Therapeutic Review
Shipping & Fulfillment
- Ships from U.S. warehouses — Florida, North Carolina, and California
- Overnight and 2-day shipping available at checkout
- Same-day processing on orders placed before cutoff
- Discreet packaging with full tracking provided
- Bulk research orders welcome — contact us for volume pricing
Storage & Handling
- Store lyophilized peptide at -20°C away from light and moisture
- After reconstitution, store at 2–8°C and use promptly
- Avoid repeated freeze-thaw cycles to maintain integrity
- Handle using appropriate laboratory safety protocols
- Keep containers sealed when not in use
Frequently Asked Questions
What is MOTS-C?
MOTS-C is a 16 amino acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA gene. It is supplied strictly for scientific, analytical, and in-vitro laboratory research use only.
What makes MOTS-C unique compared to other research peptides?
Unlike most peptides encoded by nuclear DNA, MOTS-C is encoded by mitochondrial DNA and translated in the cytoplasm. This makes it part of a rare and actively studied class of mitochondrial-derived peptides with distinct signaling properties of interest to researchers.
What purity is your MOTS-C?
Every batch is independently verified to ≥99% HPLC purity. A Certificate of Analysis is available for each lot.
How fast does Nextday Peptides ship?
We ship from U.S. warehouses in Florida, North Carolina, and California. Overnight and 2-day shipping options are available. Most orders process same day.
Are bulk orders available?
Yes. We accommodate bulk research orders. Contact us directly for volume pricing and availability.
Is this product approved for medical use?
No. This product is for laboratory research use only. It is not approved for human or veterinary use, and is not intended for diagnostic, therapeutic, or clinical applications.
What other compounds does Nextday Peptides carry?
We stock a full range of research peptides including Retatrutide GLP-3, Semaglutide GLP-1, BPC-157, and TB-500. View our full research compounds catalog.
For Research Use Only — Not for human or veterinary consumption • Not evaluated by the FDA • Supplied by Nextday Peptides for laboratory research applications only
