Semaglutide Research Peptide (GLP1-S)
Lyophilized Format • ≥99% HPLC Purity • Ships in 1–2 Business Days • U.S. Warehouses
Semaglutide (GLP1-S), also designated NN9535, is a synthetic 31 amino acid GLP-1 receptor agonist analog supplied by Nextday Peptides for laboratory and analytical research applications. Structurally modified from native GLP-1 with amino acid substitutions and a C-18 fatty acid chain that enhances albumin binding and stability, Semaglutide is one of the most extensively referenced incretin analogs in current metabolic research. Each vial is independently verified to ≥99% HPLC purity with a Certificate of Analysis available on request. For scientific research use only.
Compound Specifications
| Compound Name | Semaglutide / GLP1-S / NN9535 |
| Receptor Target | GLP-1 Receptor (GLP-1R) |
| Amino Acids | 31 |
| Molecular Formula | C₁₈₇H₂₉₁N₄₅O₅₉ |
| Molecular Weight | 4,113.6 g/mol |
| Form | Lyophilized powder |
| Appearance | White to off-white powder |
| Purity | ≥99% (HPLC verified) |
| Storage | -20°C lyophilized; 2–8°C after reconstitution |
| CAS Number | 910463-68-2 |
| Synonym | NN9535 |
Why Research Laboratories Select GLP1-S
Semaglutide is among the most studied GLP-1 receptor agonist analogs in current metabolic and endocrine research. Its structural modifications — including two amino acid substitutions compared to native GLP-1 and a C-18 fatty acid chain — give it enhanced stability and albumin binding properties, making it a valuable reference compound for laboratories studying sustained GLP-1 receptor activation, incretin signaling dynamics, and comparative receptor biology.
- 31 amino acid GLP-1 analog with C-18 fatty acid chain for enhanced stability in experimental settings
- Single receptor target — GLP-1R — useful for comparative studies against dual and triple agonists
- Extensively referenced in peer-reviewed literature on incretin biology and metabolic signaling
- Widely used as a reference compound in studies comparing GLP-1 class analogs
- Lyophilized format ensures stability and reproducibility across experimental runs
- Batch and lot identifiers on all labeling for full laboratory documentation compliance
Research Background
Semaglutide was first described in scientific literature in 2015 by Lau et al. in the Journal of Medicinal Chemistry. As a GLP-1 receptor agonist analog, it has been studied extensively in preclinical models examining GLP-1 receptor binding dynamics, cAMP-mediated signaling cascades, and comparative incretin pathway biology. All information provided here is for educational and reference purposes only and does not constitute medical or clinical guidance.
Reference sources: PubChem — Semaglutide
Shipping & Fulfillment
- Ships from U.S. warehouses — Florida, North Carolina, and California
- Overnight and 2-day shipping available at checkout
- Same-day processing on orders placed before cutoff
- Discreet packaging with full tracking provided
- Bulk research orders welcome — contact us for volume pricing
Storage & Handling
- Store lyophilized peptide at -20°C away from light and moisture
- After reconstitution, store at 2–8°C and use promptly
- Avoid repeated freeze-thaw cycles to maintain integrity
- Handle using appropriate laboratory safety protocols
- Keep containers sealed when not in use
Frequently Asked Questions
What is Semaglutide GLP1-S?
Semaglutide (NN9535) is a synthetic 31 amino acid GLP-1 receptor agonist analog with structural modifications that enhance its stability compared to native GLP-1. It is supplied strictly for scientific, analytical, and in-vitro laboratory research use only.
How does Semaglutide differ from Tirzepatide and Retatrutide?
Semaglutide targets only the GLP-1 receptor, making it a single receptor agonist. Tirzepatide targets both GIP and GLP-1 receptors (dual agonist). Retatrutide targets GLP-1, GIP, and glucagon receptors (triple agonist). This makes Semaglutide a key reference compound for comparative single-receptor studies in laboratory settings.
What purity is your Semaglutide?
Every batch is independently verified to ≥99% HPLC purity. A Certificate of Analysis is available for each lot.
How fast does Nextday Peptides ship?
We ship from U.S. warehouses in Florida, North Carolina, and California. Overnight and 2-day shipping options are available. Most orders process same day.
Are bulk orders available?
Yes. We accommodate bulk research orders. Contact us directly for volume pricing and availability.
Is this product approved for medical use?
No. This product is for laboratory research use only. It is not approved for human or veterinary use, and is not intended for diagnostic, therapeutic, or clinical applications.
What other compounds does Nextday Peptides carry?
We stock a full range of research peptides including Retatrutide GLP-3, Tirzepatide GLP-2T, BPC-157, and TB-500. View our full research compounds catalog.
For Research Use Only — Not for human or veterinary consumption • Not evaluated by the FDA • Supplied by Nextday Peptides for laboratory research applications only
