SLU-PP-332 Research Compound (Pan-ERR Agonist)
Powder Vial Format • ≥99% HPLC Purity • Ships in 1–2 Business Days • U.S. Warehouses
SLU-PP-332 (SR9861, CAS 303760-60-3) is a synthetic benzamide-scaffold compound and first-in-class pan-agonist of the estrogen-related receptors ERRα, ERRβ, and ERRγ, originally developed at Saint Louis University School of Medicine, supplied by Nextday Peptides in powder vial format for laboratory and analytical research applications. As a non-toxic pan-ERR agonist with EC50 values of 98 nM, 230 nM, and 430 nM for ERRα, ERRβ, and ERRγ respectively, SLU-PP-332 is one of the most studied exercise mimetic compounds in current mitochondrial biology and metabolic research. Each vial is independently verified to ≥99% HPLC purity with a Certificate of Analysis available on request. For scientific research use only.
Compound Specifications
| Compound Name | SLU-PP-332 / SR9861 / ERR pan-Agonist 332 |
| Formal Name | (E)-4-Hydroxy-N′-(naphthalen-2-ylmethylene)benzohydrazide |
| Receptor Targets | ERRα (EC50 98 nM), ERRβ (EC50 230 nM), ERRγ (EC50 430 nM) |
| Scaffold | Synthetic benzamide / benzohydrazide |
| Molecular Formula | C₁₈H₁₄N₂O₂ |
| Molecular Weight | 290.32 g/mol |
| CAS Number | 303760-60-3 |
| Form | Powder vial |
| Appearance | Yellow to off-white crystalline powder |
| Purity | ≥99% (HPLC verified) |
| Solubility | DMSO (58 mg/mL); Ethanol (2 mg/mL); Water (insoluble) |
| Storage | 2–8°C; DMSO solutions stable at -20°C for up to 3 months |
| Synonyms | SR9861, ERR pan-Agonist 332, SLUPP-332, SLU PP 332 |
Why Research Laboratories Select SLU-PP-332
SLU-PP-332 is the first identified synthetic pan-agonist of all three estrogen-related receptor isoforms (ERRα, ERRβ, ERRγ) — a landmark distinction that makes it an irreplaceable tool for laboratories investigating ERR-mediated mitochondrial biogenesis, skeletal muscle metabolism, and exercise-adaptive cellular responses. Its classification as an exercise mimetic compound — activating an acute aerobic exercise genetic response via DDIT4 induction — has made it one of the most discussed compounds in metabolic biology research since its characterization by Billon et al. in 2023.
- First-in-class pan-ERR agonist — simultaneously activates ERRα, ERRβ, and ERRγ isoforms
- Highest potency at ERRα (EC50 98 nM) — primary regulator of mitochondrial biogenesis and oxidative metabolism
- Exercise mimetic classification — activates acute aerobic exercise genetic response via DDIT4 induction in preclinical models
- Increases fast oxidative skeletal muscle fibers (Type IIa) in rodent models — published in ACS Chemical Biology (2023)
- Selective over ERα, ERβ, and several closely related nuclear receptors in laboratory assays
- Non-toxic profile in preclinical cell-based models — noted in Sigma-Aldrich reference documentation
- Referenced at Sigma-Aldrich, MedChemExpress, Cayman Chemical, and ACS Chemical Biology
- Batch and lot identifiers on all labeling for full laboratory documentation compliance
Research Background
SLU-PP-332 was developed at Saint Louis University School of Medicine as part of a program investigating synthetic ERR modulators. Billon et al. (2023) published landmark findings in ACS Chemical Biology demonstrating that SLU-PP-332 induces an ERRα-dependent acute aerobic exercise genetic response and enhances exercise capacity in rodent models. The compound increased fast oxidative skeletal muscle fibers (Type IIa) and exercise endurance in mice in an ERRα-specific manner. It has subsequently been referenced in metabolic disease, skeletal muscle biology, and mitochondrial biogenesis research. All information provided here is for educational and reference purposes only and does not constitute medical or clinical guidance.
Reference sources: Sigma-Aldrich — SLU-PP-332 (SML3908) | Billon et al. (2023) — ACS Chemical Biology
Shipping & Fulfillment
- Ships from U.S. warehouses — Florida, North Carolina, and California
- Overnight and 2-day shipping available at checkout
- Same-day processing on orders placed before 3:30 PM ET
- Discreet packaging with full tracking provided
- Bulk research orders welcome — contact us for volume pricing
Storage & Handling
- Store powder at 2–8°C away from light and moisture
- First dissolve in DMSO at 75 mg/mL, then dilute to aqueous buffer as needed
- DMSO solutions are stable at -20°C for up to 3 months
- Insoluble in water — do not attempt direct aqueous dissolution
- Handle using appropriate laboratory safety protocols for synthetic small molecule compounds
- Keep containers tightly sealed when not in use
Frequently Asked Questions
What is SLU-PP-332?
SLU-PP-332 (SR9861, CAS 303760-60-3) is a synthetic benzamide-scaffold compound and first-in-class pan-agonist of all three estrogen-related receptor isoforms — ERRα, ERRβ, and ERRγ. It was originally developed at Saint Louis University School of Medicine. Supplied strictly for scientific, analytical, and in-vitro laboratory research use only.
What are estrogen-related receptors (ERRs)?
Estrogen-related receptors (ERRα, ERRβ, ERRγ) are a family of orphan nuclear receptors that regulate mitochondrial biogenesis, oxidative phosphorylation, fatty acid oxidation, and glucose metabolism. Unlike estrogen receptors (ERα, ERβ), ERRs do not bind estrogen — they are regulated by metabolic coactivators including PGC-1α and are considered primary regulators of cellular energy metabolism. SLU-PP-332 selectively targets ERRs without significant activity at estrogen receptors in laboratory assays.
Why is SLU-PP-332 called an exercise mimetic?
In preclinical rodent studies published in ACS Chemical Biology (2023), SLU-PP-332 was found to activate an acute aerobic exercise genetic response via DDIT4 induction, increase fast oxidative skeletal muscle fibers (Type IIa), and enhance exercise endurance — changes typically associated with aerobic training adaptations. These findings in laboratory models have led researchers to classify it as an exercise mimetic compound for research purposes.
How should SLU-PP-332 be dissolved for laboratory use?
SLU-PP-332 is insoluble in water. For laboratory use, first dissolve in DMSO at up to 75 mg/mL, then dilute to the desired concentration in aqueous buffer. DMSO stock solutions are stable at -20°C for up to 3 months.
What purity is your SLU-PP-332?
Every batch is independently verified to ≥99% HPLC purity. A Certificate of Analysis is available for each lot.
How fast does Nextday Peptides ship?
We ship from U.S. warehouses in Florida, North Carolina, and California. Overnight and 2-day shipping options are available. Orders placed before 3:30 PM ET are processed same day.
Are bulk orders available?
Yes. We accommodate bulk research orders. Contact us directly for volume pricing and availability.
Is this product approved for medical use?
No. This product is for laboratory research use only. It is not approved for human or veterinary use, and is not intended for diagnostic, therapeutic, or clinical applications.
What other compounds does Nextday Peptides carry?
We stock a full range of research compounds including MOTS-C, NAD+, Retatrutide GLP-3, and AOD-9604. View our full research compounds catalog.
For Research Use Only — Not for human or veterinary consumption • Not evaluated by the FDA • Supplied by Nextday Peptides for laboratory research applications only
