AICAR
Powder • ≥99% HPLC Purity • Ships from U.S. Facilities • Research Use Only
AICAR (5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, Acadesine, CAS 2627-69-2) is a cell-permeable synthetic purine nucleoside analog and indirect activator of AMP-activated protein kinase (AMPK), supplied by Nextday Peptides in powder format for laboratory and analytical research applications. AICAR is taken up into cells via adenosine transporters and phosphorylated by intracellular adenosine kinase to its active form ZMP (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl-5′-monophosphate) — an AMP analog that mimics the allosteric activating effects of AMP on the AMPK heterotrimer complex without affecting cellular AMP/ATP ratios directly. This indirect, ZMP-mediated AMPK activation mechanism makes AICAR one of the most widely used pharmacological tools in cellular energy sensing and metabolic pathway research. For scientific research use only.
Compound Specifications
| Compound Name | AICAR / Acadesine / 5-Aminoimidazole-4-carboxamide ribonucleoside / AICA Riboside |
|---|---|
| Molecular Formula | C₉H₁₄N₄O₅ |
| Molecular Weight | 258.23 g/mol |
| CAS Number | 2627-69-2 |
| Form | Powder |
| Appearance | White to off-white crystalline powder |
| Purity | ≥99% (HPLC verified) |
| Storage | -20°C; stable ≥2 years when stored properly |
| Solubility | Water (up to 15 mg/mL); DMSO (soluble) |
| Classification | Purine nucleoside analog — indirect AMPK activator via ZMP metabolite |
| Mechanism | Phosphorylated by adenosine kinase → ZMP → allosteric AMPK activation |
| Primary Target | AMPK (AMP-Activated Protein Kinase) — via ZMP AMP mimicry |
| Intended Use | Laboratory / analytical / scientific research only |
Research Background
In controlled laboratory settings, investigators study AICAR as a defined research material with characterized identity specifications suitable for analytical workflows. Common research synonyms / identifiers: AICAR / Acadesine / 5-Aminoimidazole-4-carboxamide ribonucleoside / AICA Riboside. Published literature and institutional protocols should be consulted by qualified personnel. Nextday Peptides does not provide experimental protocols for human use.
Storage & Handling
-20°C; stable ≥2 years when stored properly
- Use appropriate PPE and laboratory safe-handling practices.
- Reconstitute only with solvents suitable for your research method (e.g., sterile water, bacteriostatic water, or other protocol-defined vehicles).
- Do not use if packaging is compromised; contact support for lot documentation questions.
- Dispose of materials according to institutional chemical waste rules.
Shipping & Fulfillment
Orders are processed from U.S. facilities. Most in-stock research materials ship within 1–2 business days. Overnight options may be available where eligibility and destination allow. Packaging is selected to protect laboratory materials during transit.
Research Use Only
All products offered by Nextday Peptides are intended strictly for laboratory, analytical, and scientific research use only. They are not for human or veterinary consumption, clinical use, diagnostic use, or household use. Nothing on this page is medical advice. Resale for unlicensed or non-research purposes is prohibited. By purchasing, the buyer confirms they are a qualified research end-user and will handle materials in accordance with applicable laws and laboratory safety practices.
Frequently Asked Questions
Is AICAR for human use?
No. This material is sold strictly for laboratory and scientific research. It is not a drug, supplement, or cosmetic, and is not for human or animal consumption.
Do you provide a Certificate of Analysis?
Yes. Lot-specific Certificates of Analysis (including HPLC purity where applicable) are available upon request for research documentation.
How should laboratories store this material?
Follow the storage guidance in the product specifications and your institutional SOPs. Lyophilized peptides are typically stored frozen, protected from light and moisture.
Who may purchase research materials?
Purchasers should be qualified research end-users who will use materials only in compliant laboratory contexts. Nextday Peptides reserves the right to refuse orders that fall outside research use.
