CJC-1295 Research Guide: DAC versus Mod GRF 1-29

What this CJC-1295 research guide covers

Purchasing tickets for “CJC-1295” fail in a specific way: two different peptides share a family nickname. One is modified GRF 1-29 (often sold as CJC-1295 without DAC). The other is CJC-1295 with DAC, the albumin-binding maleimido construct ConjuChem developed as DAC:GRF. Labs that treat those names as fill-size variants receive the wrong residue count, the wrong CAS, and a methods section that no longer matches the freezer.

This guide is the identity document for that fork. It covers sequence length, the four substitutions that define Mod GRF 1-29, the DAC lysine that defines CAS 446262-90-4, the Teichman 2006 paper as published context, and the catalog pages that actually correspond to those facts: CJC-1295 with DAC, CJC-1295 without DAC, the CJC / ipamorelin without-DAC blend, ipamorelin, and sermorelin. The three-component tesamorelin / ipamorelin / CJC blend is a neighbor, not a synonym.

Nextday Peptides sells Research Use Only materials. Papers cited below describe what investigators published about GHRH analogs in people or in animals. Those papers do not authorize dosing, injection, cycles, anti-aging use, or personal reconstitution. If your work is not laboratory research under an institutional SOP, this page is the wrong resource.

If you need the use boundary in a purchasing file, read Research Use Only peptides explained. If you need naming hygiene for other catalog collisions, read catalog names, CAS, and peptide identifiers. The rest of this article assumes you already know you are buying reagents.

Why CJC-1295 names collide on purchase orders

Research catalogs inherited a messy oral tradition. “CJC-1295” began as the ConjuChem code for the DAC-bearing GHRH analog. Forums and storefronts later applied the same string to the tetrasubstituted 29-mer that is the peptide core without the Drug Affinity Complex. The without-DAC molecule is more accurately called modified GRF 1-29 or Mod GRF 1-29. Calling both “CJC” is how a purchaser ships albumin-binding chemistry into an assay that wanted a short GHRH fragment.

Write the residue count on the requisition. Twenty-nine amino acids without a maleimido lysine is Mod GRF. Thirty residues with the DAC lysine is CJC-1295 with DAC. If the protocol only says “CJC,” stop and ask the PI which paper they cited. Teichman 2006, Jette 2005, Ionescu 2006, and Alba 2006 are DAC-construct papers. A binding assay that used Mod GRF as a GHRH-receptor ligand may not tolerate the extra chemistry.

Storefront titles on this site keep the distinction in the slug: with DAC versus without DAC. Use those slugs in the purchase order comment, not a screenshot of a nickname. Catalog suffixes are navigation. Sequence and CAS are identity. A blend SKU that mentions both CJC and ipamorelin is a third identity, not a convenience pack of the first two.

We see the same receiving tickets on this family that we see on incretin analogs: a lot string that never reaches the freezer log, two vials in one unlabeled bag, and a COA filed under the student’s preferred synonym. Fix the name at intake. HPLC purity cannot rescue a 29-mer that was logged as a 30-mer.

Search queries such as “cjc 1295 dac vs no dac” and “mod grf 1-29” are identity questions. Answer them with residue count and CAS, then open the matching product page. Forum threads that treat DAC as a software-style “version upgrade” are not a source. Peptide constructs are different molecules. Train purchasing staff to hear “upgrade my CJC” as a cue to slow down and ask which CAS and which residue count.

Mod GRF 1-29: the 29-residue analog (CJC-1295 without DAC)

CJC-1295 without DAC is the catalog page for modified GRF 1-29. The peptide is a 29-amino-acid analog of growth hormone-releasing hormone (GHRH / GRF) 1-29. Four substitutions distinguish it from native GHRH 1-29: D-alanine at position 2, glutamine at position 8, alanine at position 15, and leucine at position 27. Those changes were introduced to reduce enzymatic cleavage relative to the native fragment, especially dipeptidyl peptidase-IV attack at the N-terminus.

Native GHRH 1-29 is the other 29-mer in this neighborhood. On this site that analog is sermorelin (sermorelin acetate in older pharmaceutical labeling). Sermorelin is not Mod GRF. It lacks the D-Ala2 / Gln8 / Ala15 / Leu27 pattern. If a protocol cites sermorelin or GHRH 1-29 amide, do not silently substitute the modified analog because both vials say “29 aa” on a spec table. Residue identity is the experiment.

Labs pick Mod GRF when they want a GHRH-receptor ligand without the albumin-binding maleimide. That is a coherent in-vitro or analytical choice: shorter construct, no DAC warhead, literature that discusses tetrasubstituted GRF 1-29 rather than DAC:GRF pharmacokinetics. It is the wrong choice if the grant named CJC-1295 as the ConjuChem albumin-binding peptide. Read the citation’s structure figure before you open the cart.

Document the substitutions on the notebook line, not only the nickname. “Mod GRF 1-29 (D-Ala2, Gln8, Ala15, Leu27), lot …, COA filed …” is a complete identity sentence. “CJC, the short one” is not. When staff turnover hits, the substitutions are what a new student can still verify against a spec table.

Form factor is the usual lyophilized cake. Follow the lot storage line and your institutional SOP. Shared freezer rules are the same as for any high-value peptide: seated stoppers, short humid opens, frost-rated tags. See lyophilized peptide storage. Dry-cake discipline does not make Mod GRF interchangeable with the DAC construct sitting in the next rack.

CJC-1295 with DAC: 30 aa, CAS 446262-90-4, maleimido lysine

CJC-1295 with DAC is the catalog page for the Drug Affinity Complex analog. The published construct is a tetrasubstituted GRF 1-29 core plus a C-terminal lysine bearing a maleimidopropionamide (or equivalent maleimido) group. That extra functionalized lysine is why the residue count is 30 and why CAS 446262-90-4 points at this substance rather than at Mod GRF 1-29. DAC:GRF is the older ConjuChem synonym.

Jette and colleagues (Endocrinology, 2005; PMID 15817669) described maleimido GRF 1-29 derivatives that bioconjugate to the free thiol on Cys34 of serum albumin. They identified CJC-1295 as the analog that remained detectable in rat plasma beyond 72 hours and that appeared on the albumin band on Western blot after administration in that preclinical study. The maleimide is the point of the molecule. Stripping it in your head and calling the remainder “the same peptide” is how a purchase order goes wrong.

CAS 446262-90-4 belongs on the requisition when your inventory system can hold it. Do not paste that CAS onto a without-DAC line to satisfy a required field. Wrong CAS is worse than blank CAS. Blends do not inherit the DAC CAS. If the page is the without-DAC blend, the identity is two sequences in one vial, not CAS 446262-90-4.

Albumin-binding chemistry also changes how a lab should think about solution-phase work. A maleimide can react with thiols. Institutional SOPs that already control maleimide reagents (labeling kits, cysteine-reactive probes) should treat the DAC analog as that class of electrophile, not as an inert 29-mer. We do not publish consumer mixing recipes. Your chemical-hygiene plan and SDS review govern solvents and quench steps for analytical prep.

If the protocol says DAC:GRF, CJC-1295 with DAC, or CAS 446262-90-4, buy that page. If it says Mod GRF or CJC-1295 without DAC, buy the 29-mer. If someone wrote “CJC-1295” and cited Teichman, they almost certainly meant the DAC construct. Ask before the label prints.

Teichman 2006 and related papers as published context only

Teichman, Neale, Lawrence, Gagnon, Castaigne, and Frohman reported “Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults” in the Journal of Clinical Endocrinology and Metabolism in 2006 (PMID 16352683). The paper describes randomized, placebo-controlled, ascending-dose work with the DAC-bearing analog. It is the citation most purchasing files attach when a PI says “the JCEM CJC paper.”

Ionescu and Frohman (JCEM 2006; PMID 17018654) examined GH pulsatility after CJC-1295 in healthy men and reported that pulsatility was preserved while trough and mean GH and IGF-I rose in that study. Alba and colleagues (Am J Physiol Endocrinol Metab 2006; PMID 16822960) reported that once-daily CJC-1295 normalized growth in GHRH knockout mice under their schedule, with less complete effects at longer intervals. Those are published experimental results. They are not reconstitution instructions and they are not a reason to administer a research vial.

Cite these papers in a background paragraph the way you would cite any discovery dossier: to identify which analog the authors used and what they measured. Do not transcribe clinical or animal dose arms onto a research purchase order. Do not treat a lyophilized catalog cake as the clinical presentation used in 2006. Nextday Peptides is not ConjuChem, and a research SKU is not a drug product.

When a student pastes a Teichman figure into a group chat and says “order that,” the receiving job is to confirm DAC versus Mod GRF, then to file the lot. The figure does not pick a blend, does not pick sermorelin, and does not pick ipamorelin. Adjacent SKUs are adjacent on purpose. They are still different line items.

“CJC-1295 half life” is a literature query. Answer it with the Teichman citation and a sentence that half-life language in a 2006 clinical-research paper is not a specification for the bottle on the dock. Then point the buyer back to DAC status on the PO. A JCEM paper identifies a construct. It does not replace a lot COA.

Side-by-side identity for the CJC-1295 catalog family

Use the table as a receiving aid. If a cell disagrees with the lot file in your hand, the lot file wins. If a cell disagrees with a forum chart, the table and the lot file win. The only substitution that is ever valid is the one a signed method explicitly allows — and most GHRH methods do not allow DAC and Mod GRF to stand in for each other.

A blend cannot satisfy a methods citation that named one sequence. A native 29-mer cannot satisfy a citation that named the tetrasubstituted analog. A DAC construct cannot satisfy a citation that named Mod GRF. Write the row you mean on the purchase order. Keep a printed copy of this table in the ordering SOP; people will not reread a long guide at 4:55 p.m., but they will read a table if it sits in the purchasing template.

Ipamorelin and the without-DAC blend are different experiments

Ipamorelin is not a GHRH analog. Raun and colleagues (Eur J Endocrinol 1998; PMID 9849822) described it as a pentapeptide GH secretagogue (Aib-His-D-2-Nal-D-Phe-Lys-NH2) that acts at the GHRP-type receptor — the receptor later identified as the ghrelin receptor — with a selectivity profile they contrasted to GHRP-6 and GHRP-2 in that paper. A lab that needs a GHRH-receptor ligand and a lab that needs a GHS-R ligand are running different panels.

The CJC-1295 / ipamorelin without-DAC blend is a two-component SKU. It exists for groups whose signed method uses both sequences in one preparation under their own SOP. It is the wrong page if the protocol needs a single reference standard, a single CAS, or a single HPLC identity peak. You cannot un-blend a vial on paper. If you need only Mod GRF or only ipamorelin, buy the single-compound page.

We still hear “CJC/IPA” used as if it were a synonym for CJC-1295. It is not. Log the blend as a blend. File two sequences or a blend COA, not a DAC CAS. Keep the blend physically separate from single-compound stock so a night-shift colleague cannot grab the wrong stopper because the bag said CJC.

Related secretagogue pages in the catalog — GHRP-6, hexarelin — are also not ipamorelin and not GHRH. If the panel is “GHRH analog versus GHS-R ligand,” name both classes in the notebook. Nickname soup is how a blend becomes folklore.

• Ipamorelin is a pentapeptide GHS-R / GHRP-receptor ligand, not a 29-mer GHRH analog
• The without-DAC blend is two identities; do not file it under CAS 446262-90-4
• Single-compound pages exist so a methods citation can name one sequence
• GHRP-6 and hexarelin are neighbors, not substitutes, for ipamorelin

Sermorelin, tesamorelin, and other GHRH-family neighbors

Sermorelin is the catalog page for the native GHRH 1-29 fragment historically formulated as sermorelin acetate (Geref in older U.S. labeling). It is the right reference when the protocol cites GHRH 1-29 or sermorelin. It is the wrong reference when the protocol cites Mod GRF’s substitution set or the DAC construct. Twenty-nine residues is a length, not a unique key.

Tesamorelin is a different GHRH analog (a stabilized N-terminal design used in a distinct pharmaceutical program; Falutz and colleagues reported a sponsor study in HIV-associated lipodystrophy). Tesamorelin blends on this site — tesamorelin / ipamorelin and tesamorelin / ipamorelin / CJC — are again multi-component SKUs. Do not satisfy a tesamorelin citation with CJC-1295, and do not satisfy a CJC-1295 citation with tesamorelin. Analog names are not interchangeable because they share a receptor family.

When a grant says “a GHRH analog,” force a structure. Ask for residue count, substitutions, DAC yes/no, and CAS if the inventory system uses it. That four-field answer picks a page. “Whatever CJC you have in stock” is how a year of assays cites the wrong paper.

Purity work sits after identity. Use how to read a COA and how laboratories evaluate peptide purity once you know which analog you hold. Comparing HPLC percentages across a 29-mer and a maleimido 30-mer without naming the sequences is numerology.

COA, lot, and freezer identity for CJC-family SKUs

Assign each analog its own box or rack slot. Write the exact catalog name, “with DAC” or “without DAC,” lot, and date received on a frost-rated tag. Photograph the label at intake. If you hold both the 29-mer and the 30-mer, do not rely on fill size or cake appearance to tell them apart. Appearance is a lyophilization outcome, not a sequence assay.

File PDFs from the COA Library with the lot string in the file name. “cjc-new.pdf” is how the DAC file overwrites the Mod GRF file. Include CAS 446262-90-4 only on the DAC record. Include the four substitutions on the Mod GRF record. Blend files should say blend in the file name.

Purchase orders should list the slug, the residue count, and “single-compound SKU, not blend” when that is what the method needs. Purchasing agents should not have to infer DAC from a Slack nickname. If the PI cited Teichman, put PMID 16352683 in the comment so receiving knows which row of the table you meant.

When a second lot arrives, read the new COA. Do not inherit last year’s storage line or last year’s identity note. Process changes happen. Cross-lot comparisons are only valid when both lots are the named analog. Keep RUO labeling intact on any lab-owned secondary container.

Mass spectrometry should be consistent with a 29-residue peptide plus the declared salt, or with a 30-residue DAC construct, depending on the SKU. If you order no-DAC and the theoretical mass on the PDF matches a DAC listing, quarantine the vial. Related-substance peaks on GHRH analogs include deletion sequences and oxidation. You will not assign every peak from a storefront PDF. You can reject cropped chromatograms and “99%” stamps with no method.

• Separate boxes for with-DAC, without-DAC, blend, ipamorelin, and sermorelin
• Lot string in the PDF name; CAS only on the DAC record
• Photograph labels before frost lifts characters
• Quarantine any vial whose name disagrees with the packing list

Domestic shipping and laboratory storage after delivery

Nextday Peptides fulfills from U.S. warehouses in Florida, North Carolina, and California. Same-day processing targets orders placed before 3:30 PM Eastern, Monday–Saturday, after payment clears — details live in the shipping and delivery policy. Transit is not a validated pharmaceutical cold chain for every SKU. Plan receiving so vials move into labeled lab storage promptly.

A multi-SKU GHRH order that ships in one carton is still several identities. Open the carton as separate lots. Confirm each vial against the packing list before any freezer placement. Mixing CJC-1295 with DAC and CJC-1295 without DAC in one unlabeled bag is the failure mode this entire guide exists to prevent.

Solution prep, when the method requires it, is institutional work. We do not publish consumer mixing guides, pin charts, or personal-use recipes. Follow the signed SOP for solvents, concentrations as prepared for the assay, and aliquot labels (compound, lot, concentration, solvent, date, owner). Keep working solutions physically separate from dry stock.

If a package arrives damaged or the packing list does not match the DAC versus Mod GRF split you ordered, photograph everything and contact orders@nextdaypeptides.com within the window in the returns policy. Do not assign a mismatched lot to a study while you wait. Quarantine is cheaper than a year of mis-cited data.

Writing a CJC-1295 requisition a receiving dock can execute

A good requisition is dull. One line per SKU. Slug, fill, “with DAC / CAS 446262-90-4” or “without DAC / Mod GRF 1-29 / 29 aa,” and a citation if the PI has one. If you also need ipamorelin, add a second line instead of defaulting to the blend. If you also need sermorelin as a native-fragment control, add a third line. Intent that lives only in someone’s head dies at shift change.

Institutional addresses belong on the ship-to. This catalog is Research Use Only. Home, gym, and clinic drawers are the wrong destinations. Completing checkout does not create a consumer indication. If someone on the team is still thinking in retail terms, send them the RUO article before they write the PO.

Payment must clear before the 3:30 PM Eastern cutoff counts. Coordinate the method on the payments page with a person who can receive. A correctly specified DAC vial that sits in a loading dock over a holiday weekend is still a receiving failure. First-received discipline belongs in the same SOP as the identity table.

If you take only one operational upgrade from this guide, add “DAC yes/no” as a required field on every CJC-family order. That single checkbox prevents the majority of the tickets we see. Everything else — COA filing, freezer slots, blend avoidance — gets easier once the checkbox exists.

Research Use Only: what this CJC-1295 guide is not

Nextday Peptides sells Research Use Only material not for human or veterinary use. This article exists so a laboratory can tell two GHRH-family peptides apart and order the one the method named. It does not recommend CJC-1295, Mod GRF, ipamorelin, or sermorelin for growth, fat loss, sleep, anti-aging, or any personal outcome. It does not provide dosing, injection technique, or cycle length.

Teichman 2006, Ionescu 2006, Jette 2005, Alba 2006, and Raun 1998 are cited as published scientific context. They are not standing orders to administer a research vial and not templates for a consumer protocol. A research cake is not the clinical or veterinary presentation used in a paper.

If a purchasing desk needs a one-line restriction: materials are supplied for laboratory research only; they are not drugs, not supplements, and not for administration to people or animals. Keep that line on the PO and on secondary containers.

When a new student inherits a box labeled only “CJC,” treat it as unverified inventory. Do not use it until DAC status, lot, and COA are reconstructed or the vial is retired. Unidentified GHRH analog powder is not a savings. It is a methods risk and a compliance gap. If the group cannot reconstruct the lot, dispose of the material under the institutional chemical-hygiene plan rather than “using it up” to avoid waste.

Bottom line for lab buyers ordering CJC-1295

Say residue count and DAC in the same sentence. Mod GRF 1-29 is 29 amino acids with D-Ala2, Gln8, Ala15, and Leu27 — CJC-1295 without DAC. CJC-1295 with DAC is the 30-residue maleimido albumin-binding analog, CAS 446262-90-4 — CJC-1295 with DAC. Teichman 2006 studied the latter class of construct. Sermorelin is the native 29-mer. Ipamorelin is a different receptor. Blends are blends.

Then bind the vial you actually receive to a lot file and a freezer location that still makes sense after frost. That is the quality system a compound guide can honestly offer. Shipping, storage, and purity reading have their own pages. This page is the identity fork.

If a protocol is still using the bare nickname “CJC-1295,” return it to the PI with the table above. Ambiguous nicknames are cheaper to fix on paper than after a month of assays. Shop the full catalog when the protocol names something else.