Kisspeptin-10 Research Peptide (KP-10)
Lyophilized Format • Lot COA (review the certificate for reported results) • Ships in 1–2 Business Days • U.S. Warehouses
Kisspeptin-10 (KP-10, CAS 374675-21-5) is a synthetic C-terminally amidated decapeptide representing the minimal active C-terminal sequence of the endogenous KISS1 gene product (kisspeptin-54/metastin), supplied by Nextday Peptides for laboratory and analytical research applications. As the shortest kisspeptin fragment retaining full intrinsic agonist activity at the KISS1R receptor (GPR54), Kisspeptin-10 is one of the most widely used research tools in reproductive endocrinology, neuroendocrine signaling, and hypothalamic-pituitary-gonadal (HPG) axis biology. Lot documentation / COA available. Review the applicable certificate for reported test results and methodology. Nextday Peptides does not independently test each lot in-house. For scientific research use only.
Compound Specifications
| CAS Number |
374675-21-5 |
| Form |
Lyophilized powder |
| Appearance |
White to off-white powder |
| Purity |
As reported on the lot COA |
| Storage |
Lyophilized material is typically stored frozen per the SDS and institutional SOP. Solution-phase storage, if any, is the laboratory’s responsibility and is not specified here. |
| Synonyms |
KP-10, Metastin(45–54), KISS1(112–121), KISS1R agonist, GPR54 ligand |
Why Research Laboratories Select Kisspeptin-10
Kisspeptin-10 is the minimal active sequence of the kisspeptin family and the most widely used kisspeptin isoform in laboratory research. As a full agonist at KISS1R/GPR54 with potency comparable to kisspeptin-54, it enables precise investigation of GPR54-mediated signaling without the added complexity of longer kisspeptin variants. Its role as an upstream regulator of GnRH neuron activation makes it an essential reference compound for laboratories investigating HPG axis biology, reproductive neuroendocrinology, and gonadotropin secretion models.
- Minimal active kisspeptin fragment — 10 amino acid C-terminal sequence retaining full GPR54 agonist activity
- KISS1R/GPR54 full agonist — activates Gq/11α signaling, calcium mobilization, and ERK1/2/p38 MAPK phosphorylation in experimental systems
- Key upstream regulator of GnRH neuron activation — studied in HPG axis, LH and FSH secretion, and reproductive neuroendocrine research models
- Originally identified as a metastasis suppressor gene product — referenced in oncology, angiogenesis inhibition, and tumor biology research
- Referenced in peer-reviewed literature including New England Journal of Medicine, Physiological Reviews, and Journal of Clinical Endocrinology & Metabolism
- Lyophilized format ensures stability and reproducibility across experimental runs
- Batch and lot identifiers on all labeling for full laboratory documentation compliance
Research Background
The KISS1 gene was originally identified in the 1990s as a metastasis suppressor in melanoma and breast cancer cell lines. Kotani et al. (2001) in the Journal of Biological Chemistry established that the KISS1 gene product encoded kisspeptins as natural ligands of the orphan receptor GPR54. Seminara et al. (2003) published landmark findings in the New England Journal of Medicine identifying GPR54 as a critical regulator of puberty onset in humans. Dhillo et al. (2005) in the Journal of Clinical Endocrinology & Metabolism demonstrated that kisspeptin-54 stimulated the HPG axis in human males. Kisspeptin-10 has been used extensively as the minimal active research tool across these and subsequent studies. All information provided here is for educational and reference purposes only and does not constitute medical or clinical guidance.
Reference sources: Seminara et al. (2003) — New England Journal of Medicine
Shipping & Fulfillment
- Ships from U.S. warehouses — Florida, North Carolina, and California
- Overnight and 2-day shipping available at checkout
- Same-day processing on orders placed before 3:30 PM ET
- Discreet packaging with full tracking provided
- Bulk research orders welcome — contact us for volume pricing
Storage & Handling
- Store lyophilized peptide at -20°C away from light and moisture
- After reconstitution store at 2–8°C — aliquot into single-use portions to avoid repeated freeze-thaw cycles
- Kisspeptin-10 is soluble in water (25 mg/mL) and DMSO (100 mg/mL) — insoluble in ethanol
- Avoid repeated freeze-thaw cycles to maintain compound integrity
- Handle using appropriate laboratory safety protocols
- Keep containers sealed when not in use
Frequently Asked Questions
What is Kisspeptin-10?
Kisspeptin-10 (KP-10, CAS 374675-21-5) is a synthetic C-terminally amidated decapeptide representing the minimal active C-terminal sequence of the KISS1 gene product. It is a full agonist at the KISS1R/GPR54 receptor and the most widely used kisspeptin isoform in neuroendocrine and reproductive biology research. Supplied strictly for scientific, analytical, and in-vitro laboratory research use only.
How does Kisspeptin-10 relate to kisspeptin-54?
Kisspeptin-54 (metastin) is the full 54 amino acid KISS1 gene product. Kisspeptin-10 represents the C-terminal 10 amino acids of kisspeptin-54 and is the minimal sequence required for full GPR54 agonist activity. In laboratory research Kisspeptin-10 is preferred over longer variants due to its smaller size, greater accessibility, and equivalent receptor binding potency.
What receptor does Kisspeptin-10 target?
Kisspeptin-10 targets KISS1R, also known as GPR54 — a G protein-coupled receptor expressed in hypothalamic and peripheral tissues. Activation of KISS1R by Kisspeptin-10 initiates Gq/11α signaling, intracellular calcium mobilization, and ERK1/2/p38 MAPK phosphorylation in experimental systems.
Why was Kisspeptin-10 originally studied in oncology?
The KISS1 gene was first identified as a metastasis suppressor in melanoma and breast cancer cell lines in the 1990s before its role in reproductive biology was established. Kisspeptin-10 has been studied as a tumor metastasis suppressor via GPR54 in various cancer cell line models, as well as a vasoconstrictor and inhibitor of angiogenesis in endothelial research models.
What purity is your Kisspeptin-10?
Every batch is documented on the lot Certificate of Analysis. A Certificate of Analysis is available for each lot.
How fast does Nextday Peptides ship?
We ship from U.S. warehouses in Florida, North Carolina, and California. Overnight and 2-day shipping options are available. Orders placed before 3:30 PM ET are processed same day.
Are bulk orders available?
Yes. We accommodate bulk research orders. Contact us directly for volume pricing and availability.
Is this product approved for medical use?
No. This product is for laboratory research use only. It is not approved for human or veterinary use, and is not intended for diagnostic, therapeutic, or clinical applications.
What other compounds does Nextday Peptides carry?
We stock a full range of research peptides including Sermorelin, Ipamorelin, Gonadorelin, and Retatrutide GLP-3. View our full research compounds catalog.
For Research Use Only — Not for human or veterinary consumption • Not evaluated by the FDA • Supplied by Nextday Peptides for laboratory research applications only
