Hexarelin Acetate Research Peptide (Examorelin / GHRP)
Lyophilized Format • ≥99% HPLC Purity • Ships in 1–2 Business Days • U.S. Warehouses
Hexarelin Acetate (Examorelin, CAS 140703-51-1) is a synthetic hexapeptide with the sequence His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH₂, developed as a structurally enhanced analog of GHRP-6 through systematic incorporation of a D-2-methyltryptophan residue at position 2 and a D-phenylalanine at position 6, supplied by Nextday Peptides in lyophilized format for laboratory and analytical research applications. Distinguished from other GHRPs by its uniquely high GHS-R1a binding affinity (Kd approximately 0.7 nM) and a secondary binding activity at cardiac and peripheral tissue receptor subtypes independent of GHS-R1a — making it one of the most pharmacologically broad synthetic GHRPs available for laboratory research. Each vial is independently verified to ≥99% HPLC purity with a Certificate of Analysis available on request. For scientific research use only.
Compound Specifications
| Compound Name | Hexarelin Acetate / Examorelin / GHRP-Hex |
| Peptide Sequence | His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH₂ |
| Amino Acids | 6 (Hexapeptide) |
| Receptor Target | GHS-R1a (primary) + cardiac/peripheral tissue receptor subtype (secondary, GHS-R1a independent) |
| Key Modifications vs GHRP-6 | D-2-methyl-Trp at position 2 + D-Phe at position 6 — ~30-fold increased receptor affinity |
| GHS-R1a Binding | Kd ~0.7 nM (reference data) |
| Molecular Formula | C₄₇H₅₈N₁₂O₆ |
| Molecular Weight | 887.05 g/mol (free base) |
| CAS Number | 140703-51-1 |
| Form | Lyophilized powder (acetate salt) |
| Appearance | White to off-white powder |
| Purity | ≥99% (HPLC verified) |
| Storage | -20°C lyophilized; 2–8°C after reconstitution |
| Synonyms | Examorelin, GHRP-Hex, His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH₂ |
Why Research Laboratories Select Hexarelin
Hexarelin is pharmacologically unique among GHRPs for two reasons that no other synthetic GHRP shares simultaneously: it is the most potent GHS-R1a agonist in the GHRP class with binding affinity approximately 30-fold greater than GHRP-6, and it possesses a secondary GHS-R1a-independent binding activity at cardiac and peripheral tissue receptor subtypes — producing cardiovascular research signals even in GH-blocked experimental models. This dual receptor engagement profile makes it the most pharmacologically complex synthetic GHRP available for laboratory research.
- Most potent synthetic GHRP — GHS-R1a binding affinity Kd ~0.7 nM, approximately 30-fold greater than GHRP-6
- D-2-methyl-Trp at position 2 — conformational lock increasing receptor binding affinity and proteolytic resistance
- Secondary cardiac receptor binding — GHS-R1a-independent activity studied in cardiac and peripheral tissue research models
- Activates Gq/PLC pathway — IP3/DAG/Ca²⁺ second messenger cascade in pituitary somatotroph research systems
- Studied in ischemia-reperfusion research models for cardiac receptor pathway biology
- Studied alongside Ipamorelin and GHRP-2 in comparative GHRP potency and selectivity research
- Lyophilized format ensures stability and reproducibility across experimental runs
- Batch and lot identifiers on all labeling for full laboratory documentation compliance
Research Background
Hexarelin was developed in the 1990s through systematic structure-activity relationship studies building on GHRP-6. Deghenghi et al. published early characterization data establishing Hexarelin as the most potent synthetic GHRP of its generation. Locatelli et al. published comparative potency data in the Journal of Endocrinology. Bodart et al. (1999) published findings on Hexarelin’s cardiac receptor binding independent of GHS-R1a in Circulation Research — a landmark finding establishing Hexarelin’s unique dual receptor profile. Muccioli et al. (2004) further characterized the cardiac receptor subtype in the European Journal of Pharmacology. All information provided here is for educational and reference purposes only and does not constitute medical or clinical guidance.
Reference sources: PubChem — Hexarelin | Bodart et al. (1999) — Circulation Research
Shipping & Fulfillment
- Ships from U.S. warehouses — Florida, North Carolina, and California
- Overnight and 2-day shipping available at checkout
- Same-day processing on orders placed before 3:30 PM ET
- Discreet packaging with full tracking provided
- Bulk research orders welcome — contact us for volume pricing
Storage & Handling
- Store lyophilized peptide at -20°C away from light and moisture
- After reconstitution store at 2–8°C and use within 14 days
- Avoid repeated freeze-thaw cycles to maintain peptide integrity
- Handle using appropriate laboratory safety protocols
- Keep containers sealed when not in use
Frequently Asked Questions
What is Hexarelin Acetate?
Hexarelin Acetate (Examorelin, CAS 140703-51-1) is a synthetic hexapeptide GHS-R1a agonist with the sequence His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH₂. The most potent synthetic GHRP developed — with GHS-R1a binding affinity approximately 30-fold greater than GHRP-6 — and uniquely possessing secondary GHS-R1a-independent cardiac receptor binding activity. Supplied strictly for scientific, analytical, and in-vitro laboratory research use only.
How does Hexarelin differ from Ipamorelin?
Both are synthetic hexapeptide/pentapeptide GHS-R1a agonists but with distinct profiles. Ipamorelin is a pentapeptide (5 AA) noted for high GHS-R1a selectivity and minimal cross-reactivity with other pituitary pathways — valued for its clean receptor profile. Hexarelin is a hexapeptide (6 AA) with significantly higher GHS-R1a binding potency and additional GHS-R1a-independent cardiac receptor activity — valued for its potency and dual receptor engagement in research models.
What is the D-2-methyltryptophan modification and why is it significant?
D-2-methyltryptophan (D-2-Me-Trp) is a non-canonical tryptophan derivative incorporated at position 2 of the Hexarelin sequence. The methyl group at the 2-position of the indole ring combined with D-stereochemistry creates a conformational rigidity that dramatically increases GHS-R1a receptor binding affinity compared to the standard tryptophan at position 2 in GHRP-6, while simultaneously enhancing resistance to proteolytic degradation in experimental systems.
What is the cardiac receptor binding activity of Hexarelin?
Bodart et al. (1999) published findings in Circulation Research demonstrating that Hexarelin produces cardiac effects in animal research models even when GHS-R1a-mediated GH secretion is blocked or absent. This established the existence of a distinct cardiac receptor subtype through which Hexarelin binds independently of GHS-R1a — making it a unique dual-receptor research tool within the GHRP class.
What purity is your Hexarelin Acetate?
Every batch is independently verified to ≥99% HPLC purity. A Certificate of Analysis is available for each lot.
How fast does Nextday Peptides ship?
We ship from U.S. warehouses in Florida, North Carolina, and California. Overnight and 2-day shipping options are available. Orders placed before 3:30 PM ET are processed same day.
Are bulk orders available?
Yes. We accommodate bulk research orders. Contact us directly for volume pricing and availability.
Is this product approved for medical use?
No. This product is for laboratory research use only. It is not approved for human or veterinary use, and is not intended for diagnostic, therapeutic, or clinical applications.
What other compounds does Nextday Peptides carry?
We also carry Ipamorelin, Sermorelin, CJC-1295 No DAC, and Tesamorelin. View our full research compounds catalog.
For Research Use Only — Not for human or veterinary consumption • Not evaluated by the FDA • Supplied by Nextday Peptides for controlled in-vitro laboratory research use only
