Tirzepatide Research Peptide (GLP2-T)
Lyophilized Format • ≥99% HPLC Purity • Ships in 1–2 Business Days • U.S. Warehouses
Tirzepatide (GLP2-T), also designated LY3298176, is a synthetic dual-receptor agonist peptide supplied by Nextday Peptides for laboratory and analytical research applications. Each vial is independently verified to ≥99% HPLC purity with a Certificate of Analysis available on request. For scientific research use only.
Compound Specifications
| Compound Name | Tirzepatide / GLP2-T / LY3298176 |
| Receptor Targets | GIP receptor, GLP-1 receptor (Dual Agonist) |
| Molecular Weight | 4,813.5 g/mol (free base) |
| Molecular Formula | C₂₂₅H₃₄₈N₄₈O₆₈ |
| Form | Lyophilized powder |
| Appearance | White to off-white powder |
| Purity | ≥99% (HPLC verified) |
| Storage | -20°C lyophilized; 2–8°C after reconstitution |
| CAS Number | 2023788-19-2 |
| SKU | NDP-057 |
Mechanism of Action
Tirzepatide is a 39-amino acid synthetic peptide with a C-20 fatty diacid modification that enables albumin binding and extends its half-life in research models. It simultaneously activates two incretin receptors, distinguishing it from single-receptor GLP-1 agonists such as semaglutide.
- GLP-1 receptor activation — stimulates glucose-dependent insulin secretion, suppresses glucagon release, reduces appetite signaling, and slows gastric emptying in research models
- GIP receptor activation — potentiates insulin secretion in a glucose-dependent manner, modulates adipose tissue metabolism, and contributes to energy balance regulation in preclinical studies
The dual incretin mechanism produces additive and potentially synergistic effects on insulin secretion and metabolic regulation compared to GLP-1 receptor activation alone. This makes tirzepatide a key reference compound for dual incretin pathway research and comparative receptor pharmacology studies.
Research Applications
Tirzepatide is studied across several active research domains:
- Dual incretin receptor signaling and GIP/GLP-1 receptor crosstalk studies
- Comparative receptor pharmacology alongside semaglutide (single agonist) and retatrutide (triple agonist)
- Glucose homeostasis and insulin secretion modeling in preclinical systems
- Adipose tissue metabolism and body composition research
- Appetite regulation and energy expenditure investigations
- Fatty acid modification and albumin binding pharmacokinetic studies
- Beta cell function and pancreatic insulin response research
Why Research Laboratories Select GLP2-T
Tirzepatide is one of the most extensively studied dual incretin receptor agonist peptides in current metabolic research. Its simultaneous engagement of both GIP and GLP-1 receptors makes it a highly relevant reference compound for laboratories investigating dual incretin pathway biology, glucose homeostasis models, and comparative receptor signaling in preclinical settings.
- Dual receptor profile — simultaneous GIP and GLP-1 receptor engagement in research models
- 39 amino acid synthetic peptide with C-20 fatty diacid modification for enhanced stability
- Referenced extensively in peer-reviewed literature across metabolic and endocrine research
- Useful for comparative studies alongside single GLP-1 agonists and triple receptor compounds
- Lyophilized format ensures stability and reproducibility across experimental runs
- Batch and lot identifiers on all labeling for full laboratory documentation compliance
Tirzepatide vs. Semaglutide vs. Retatrutide: Research Comparison
| Compound | Receptor Targets | Agonist Type |
| Tirzepatide (GLP2-T) | GLP-1R, GIPR | Dual agonist |
| Semaglutide | GLP-1R | Single agonist |
| Retatrutide | GLP-1R, GIPR, GCGR | Triple agonist |
This comparison table is provided for research reference only. All compounds listed are supplied for laboratory research use only and are not intended for human use.
Research Background
GLP2-T (Tirzepatide) has been referenced extensively in scientific literature as a dual GIP/GLP-1 receptor agonist. Preclinical studies in rodent and non-human primate models have examined its effects on glucose regulation, insulin secretion, body weight, and metabolic markers. Phase 3 human clinical trials have been completed and published in peer-reviewed journals. All information provided here is for educational and reference purposes only and does not constitute medical or clinical guidance.
Reference sources: PubChem — Tirzepatide | NEJM — SURPASS-2 Trial
Shipping & Fulfillment
- Ships from U.S. warehouses — Florida, North Carolina, and California
- Overnight and 2-day shipping available at checkout
- Same-day processing on orders placed before cutoff
- Discreet packaging with full tracking provided
- Bulk research orders welcome — contact us for volume pricing
Storage & Handling
- Store lyophilized peptide at -20°C away from light and moisture
- After reconstitution, store at 2–8°C and use promptly
- Avoid repeated freeze-thaw cycles to maintain integrity
- Handle using appropriate laboratory safety protocols
- Keep containers sealed when not in use
Frequently Asked Questions
What is Tirzepatide GLP2-T?
Tirzepatide (LY3298176) is a synthetic 39 amino acid dual agonist peptide that simultaneously targets GIP and GLP-1 receptors. It is supplied strictly for scientific, analytical, and in-vitro laboratory research use only.
How does tirzepatide differ from semaglutide?
Semaglutide targets only the GLP-1 receptor. Tirzepatide targets both GIP and GLP-1 receptors simultaneously, making it a dual agonist. This dual receptor engagement produces distinct metabolic effects that are the subject of active comparative laboratory research.
How does tirzepatide differ from retatrutide?
Tirzepatide is a dual agonist targeting GLP-1 and GIP receptors. Retatrutide additionally targets the glucagon receptor, making it a triple agonist. Laboratories studying multi-receptor incretin biology often use both as reference compounds.
What purity is your Tirzepatide?
Every batch is independently verified to ≥99% HPLC purity. A Certificate of Analysis is available for each lot via our COA Library.
How fast does Nextday Peptides ship?
We ship from U.S. warehouses in Florida, North Carolina, and California. Overnight and 2-day shipping options are available. Most orders process same day.
Are bulk orders available?
Yes. We accommodate bulk research orders. Contact us directly for volume pricing and availability.
Is this product approved for medical use?
No. This product is for laboratory research use only. It is not approved for human or veterinary use, and is not intended for diagnostic, therapeutic, or clinical applications.
What other compounds does Nextday Peptides carry?
We stock a full range of research peptides including Retatrutide GLP-3, Semaglutide GLP-1, BPC-157, and TB-500. View our full research compounds catalog.
For Research Use Only — Not for human or veterinary consumption • Not evaluated by the FDA • Supplied by Nextday Peptides for laboratory research applications only