Selank Research Peptide (Tuftsin Analog)
Lyophilized Format • ≥99% HPLC Purity • Ships in 1–2 Business Days • U.S. Warehouses
Selank (TP-7, CAS 129954-34-3) is a synthetic heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, developed by the Institute of Molecular Genetics of the Russian Academy of Sciences as a structurally extended analog of tuftsin — a naturally occurring immunomodulatory tetrapeptide derived from the Fc region of immunoglobulin G — supplied by Nextday Peptides in lyophilized format for laboratory and analytical research applications. The Pro-Gly-Pro C-terminal extension was added to enhance metabolic stability compared to native tuftsin. Selank is studied as a research tool for investigating GABAergic neurotransmission modulation, BDNF pathway dynamics, serotonin system interactions, and neuroimmune signaling in controlled preclinical experimental systems. Each vial is independently verified to ≥99% HPLC purity with a Certificate of Analysis available on request. For scientific research use only.
Compound Specifications
| Compound Name | Selank / TP-7 / Selanc |
| Peptide Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro |
| Amino Acids | 7 (Heptapeptide) |
| Origin | Synthetic tuftsin (Thr-Lys-Pro-Arg) analog with C-terminal Pro-Gly-Pro extension |
| Parent Peptide | Tuftsin — naturally occurring IgG Fc-derived immunomodulatory tetrapeptide |
| Molecular Formula | C₃₃H₅₇N₁₁O₉ |
| Molecular Weight | 751.87 g/mol |
| CAS Number | 129954-34-3 |
| Form | Lyophilized powder |
| Appearance | White to off-white powder |
| Purity | ≥99% (HPLC verified) |
| Storage | -20°C lyophilized; 2–8°C after reconstitution |
| Synonyms | TP-7, Selanc, Thr-Lys-Pro-Arg-Pro-Gly-Pro |
Why Research Laboratories Select Selank
Selank is a unique research tool that combines tuftsin-derived immunomodulatory properties with neuromodulatory signaling activity across GABAergic, serotonergic, and BDNF pathways — making it one of the few synthetic heptapeptides with multi-system neuroimmune research applications. Its Pro-Gly-Pro C-terminal extension significantly enhances metabolic stability compared to native tuftsin, enabling longer-duration experimental protocols and more consistent assay conditions across repeated measurements.
- Synthetic tuftsin analog — Thr-Lys-Pro-Arg core extended with Pro-Gly-Pro for enhanced metabolic stability
- Studied for GABAergic neurotransmission modulation in rodent anxiety and stress response research models
- Studied for BDNF upregulation in hippocampal and cortical cell-based research systems
- Studied for serotonin (5-HT) system stabilization in preclinical neurochemistry research models
- Enkephalinase inhibition studied in preclinical opioid withdrawal and endogenous opioid pathway research
- Immunomodulatory activity studied via cytokine pathway interactions in neuroimmune research models
- Approved pharmaceutical equivalent in Russia and Ukraine — extensive published literature available
- Lyophilized format ensures stability and reproducibility across experimental runs
- Batch and lot identifiers on all labeling for full laboratory documentation compliance
Research Background
Selank was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in collaboration with the V.V. Zakusov Institute of Pharmacology. Zozulia et al. published clinical findings in Zhurnal Nevrologii i Psikhiatrii on Selank’s effects in anxiety research settings. Volkova et al. published findings in the Bulletin of Experimental Biology and Medicine on BDNF and gene expression modulation. A 2019 resting-state fMRI study (PMID: 31625062) examined Selank’s effects on functional connectivity between the amygdala and temporal cortex in 52 healthy subjects compared to Semax and placebo. All information provided here is for educational and reference purposes only and does not constitute medical or clinical guidance.
Reference sources: PubChem — Selank | PubMed — Selank fMRI Connectivity Study
Shipping & Fulfillment
- Ships from U.S. warehouses — Florida, North Carolina, and California
- Overnight and 2-day shipping available at checkout
- Same-day processing on orders placed before 3:30 PM ET
- Discreet packaging with full tracking provided
- Bulk research orders welcome — contact us for volume pricing
Storage & Handling
- Store lyophilized peptide at -20°C away from light and moisture
- After reconstitution store at 2–8°C and use within 7 days
- Aliquot into single-use portions after reconstitution to avoid repeated freeze-thaw cycles
- Handle using appropriate laboratory safety protocols
- Keep containers sealed when not in use
Frequently Asked Questions
What is Selank?
Selank (TP-7, CAS 129954-34-3) is a synthetic heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, developed as a metabolically stable analog of tuftsin — a naturally occurring immunomodulatory tetrapeptide derived from the Fc region of immunoglobulin G. It is studied in neuromodulatory signaling, BDNF pathway, GABAergic neurotransmission, and neuroimmune research. Supplied strictly for scientific, analytical, and in-vitro laboratory research use only.
What is tuftsin and how does Selank relate to it?
Tuftsin (Thr-Lys-Pro-Arg) is a naturally occurring immunomodulatory tetrapeptide produced by enzymatic cleavage of the Fc region of immunoglobulin G. Selank was created by extending the tuftsin sequence with a C-terminal Pro-Gly-Pro tripeptide, which significantly enhances the compound’s metabolic stability compared to native tuftsin while preserving and extending its neuroimmune signaling properties in experimental systems.
What signaling pathways is Selank studied in?
In preclinical research models Selank has been studied in GABAergic neurotransmission modulation, BDNF expression and signaling in hippocampal and cortical systems, serotonin (5-HT) stabilization, enkephalinase inhibition in opioid pathway research, cytokine network modulation, and hypocretin/Hcrt gene expression research. All findings are from controlled preclinical research settings.
How does Selank differ from Semax?
Selank derives from tuftsin (IgG Fc fragment) and is primarily studied for GABAergic anxiolytic pathway research with secondary BDNF-mediated nootropic effects. Semax derives from ACTH 4-10 (neurotropic ACTH fragment) and is primarily studied for dopamine-mediated cognitive and neuroprotective pathway research. They are distinct research tools from different peptide families studied in complementary neuromodulatory contexts.
What purity is your Selank?
Every batch is independently verified to ≥99% HPLC purity. A Certificate of Analysis is available for each lot.
How fast does Nextday Peptides ship?
We ship from U.S. warehouses in Florida, North Carolina, and California. Overnight and 2-day shipping options are available. Orders placed before 3:30 PM ET are processed same day.
Are bulk orders available?
Yes. We accommodate bulk research orders. Contact us directly for volume pricing and availability.
Is this product approved for medical use?
No. This product is for laboratory research use only in the United States. It is not approved by the FDA for any human or veterinary use and is not intended for diagnostic, therapeutic, or clinical applications.
What other compounds does Nextday Peptides carry?
We stock a full range of research peptides including DSIP, Thymosin Alpha-1, BPC-157, and LL-37. View our full research compounds catalog.
For Research Use Only — Not for human or veterinary consumption • Not FDA approved • Supplied by Nextday Peptides for controlled in-vitro laboratory research use only
