DSIP Research Peptide (Delta Sleep-Inducing Peptide)
Lyophilized Format • ≥99% HPLC Purity • Ships in 1–2 Business Days • U.S. Warehouses
DSIP (Delta Sleep-Inducing Peptide, CAS 62568-57-4) is a naturally occurring nonapeptide first isolated from rabbit brain in 1977, supplied by Nextday Peptides in lyophilized format for laboratory and analytical research applications. Originally isolated from the cerebral venous blood of rabbits during delta-wave sleep states by Monnier et al., DSIP is synthesized endogenously in the hypothalamus and is found in plasma, peripheral organs, and neurons. As a research tool it is studied in neuroendocrine signaling, circadian rhythm biology, neuropeptide pharmacokinetics, and stress response pathway research in controlled preclinical experimental systems. Each vial is independently verified to ≥99% HPLC purity with a Certificate of Analysis available on request. For scientific research use only.
Compound Specifications
| Compound Name | DSIP / Delta Sleep-Inducing Peptide / δ-Sleep Inducing Peptide |
| Peptide Sequence | H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH |
| Amino Acids | 9 (Nonapeptide) |
| Origin | Naturally occurring — first isolated from rabbit brain (1977, Monnier et al.) |
| Endogenous Source | Synthesized in hypothalamus; found in plasma, peripheral organs, and neurons |
| Molecular Formula | C₃₅H₄₈N₁₀O₁₅ |
| Molecular Weight | 848.84 g/mol |
| CAS Number | 62568-57-4 |
| Form | Lyophilized powder |
| Appearance | White to off-white powder |
| Purity | ≥99% (HPLC verified) |
| Storage | -20°C lyophilized; 2–8°C after reconstitution (use within 7 days) |
| Synonyms | DSIP, δ-Sleep Inducing Peptide, Sleep-Promoting Peptide |
Why Research Laboratories Select DSIP
DSIP is one of the most unique neuropeptides available for laboratory research due to its endogenous origin, blood-brain barrier permeability, and multi-system signaling properties. As a naturally occurring hypothalamic peptide found in plasma and multiple peripheral organs, it provides a research tool for studying neuropeptide distribution, neuroendocrine signaling cascades, circadian rhythm-correlated peptide dynamics, and stress response pathway biology in controlled preclinical experimental systems.
- Naturally occurring hypothalamic nonapeptide — first isolated by Monnier et al. in 1977 from rabbit brain
- Blood-brain barrier permeable — studied for CNS peptide penetration and distribution research in preclinical models
- Plasma concentrations correlated with circadian rhythm in published research — studied in circadian biology models
- Found in plasma, peripheral organs, and neurons — studied across multiple tissue compartments in preclinical systems
- Studied for interactions with multiple neuroendocrine systems including stress hormone pathways and neurotransmitter dynamics
- Referenced in peer-reviewed literature including European Journal of Anaesthesiology and multiple preclinical neuroscience journals
- Lyophilized format ensures stability and reproducibility across experimental runs
- Batch and lot identifiers on all labeling for full laboratory documentation compliance
Research Background
DSIP was first isolated from the cerebral venous blood of rabbits during delta-wave EEG states by Monnier et al. in 1977. Subsequent preclinical studies have examined its distribution across plasma, brain, and peripheral organs, its circadian rhythm-correlated plasma concentration dynamics, and its interactions with multiple neuroendocrine systems. Pollard and Pomfrett (2001) published a comprehensive review in the European Journal of Anaesthesiology covering DSIP biology and preclinical research. The FDA has noted potential immunogenicity concerns regarding compounded DSIP preparations and has not approved DSIP for any human use. All information provided here is for educational and reference purposes only and does not constitute medical or clinical guidance.
Reference sources: PubChem — DSIP | PubMed — DSIP Sleep Research
⚠️ Regulatory Notice
DSIP is not approved by the FDA for any human use. The FDA has noted potential immunogenicity concerns regarding DSIP preparations and has indicated that no safety-related information regarding DSIP in humans has been identified. This product is supplied strictly for controlled in-vitro laboratory research use only by qualified research professionals. It is not for human or veterinary use under any circumstances.
Shipping & Fulfillment
- Ships from U.S. warehouses — Florida, North Carolina, and California
- Overnight and 2-day shipping available at checkout
- Same-day processing on orders placed before 3:30 PM ET
- Discreet packaging with full tracking provided
- Bulk research orders welcome — contact us for volume pricing
Storage & Handling
- Store lyophilized peptide at -20°C away from light and moisture
- After reconstitution store at 2–8°C and use within 7 days
- For long-term reconstituted storage add carrier protein (0.1% HSA or BSA) and store at -20°C
- Avoid repeated freeze-thaw cycles to maintain peptide integrity
- Handle using appropriate laboratory safety protocols
- Keep containers sealed when not in use
Frequently Asked Questions
What is DSIP?
DSIP (Delta Sleep-Inducing Peptide, CAS 62568-57-4) is a naturally occurring nonapeptide first isolated from rabbit brain in 1977 by Monnier et al. It is synthesized endogenously in the hypothalamus and found in plasma, peripheral organs, and neurons. Supplied strictly for scientific, analytical, and in-vitro laboratory research use only.
What makes DSIP unique as a research peptide?
DSIP is notable among neuropeptides for several properties studied in laboratory research — its ability to cross the blood-brain barrier, its presence across multiple tissue compartments including plasma and peripheral organs, and its plasma concentrations that correlate with circadian rhythm dynamics in published preclinical research. These properties make it a multi-system research tool for neuroendocrine signaling and circadian biology studies.
What neuroendocrine systems has DSIP been studied in?
In preclinical research models DSIP has been examined in the context of hypothalamic-pituitary axis signaling, stress hormone pathway interactions, neurotransmitter dynamics including substance P modulation in rodent models, and circadian rhythm-correlated peptide concentration dynamics. All findings are from controlled preclinical research settings and are not representative of human clinical outcomes.
Is DSIP FDA approved?
No. DSIP is not approved by the FDA for any human use. The FDA has noted potential immunogenicity concerns and has stated that no safety-related information regarding DSIP in humans has been identified. This product is for laboratory research use only.
What purity is your DSIP?
Every batch is independently verified to ≥99% HPLC purity. A Certificate of Analysis is available for each lot.
How fast does Nextday Peptides ship?
We ship from U.S. warehouses in Florida, North Carolina, and California. Overnight and 2-day shipping options are available. Orders placed before 3:30 PM ET are processed same day.
Are bulk orders available?
Yes. We accommodate bulk research orders. Contact us directly for volume pricing and availability.
Is this product approved for medical use?
No. This product is for laboratory research use only. It is not approved for human or veterinary use, and is not intended for diagnostic, therapeutic, or clinical applications of any kind.
What other compounds does Nextday Peptides carry?
We stock a full range of research peptides including MOTS-C, Thymosin Alpha-1, BPC-157, and LL-37. View our full research compounds catalog.
For Research Use Only — Not for human or veterinary consumption • Not evaluated by the FDA • Supplied by Nextday Peptides for in-vitro laboratory research use only
