Pinealon Research Peptide (EDR / Glu-Asp-Arg Tripeptide)
Lyophilized Format • ≥99% HPLC Purity • Ships in 1–2 Business Days • U.S. Warehouses
Pinealon (EDR, Glu-Asp-Arg, CAS 175175-23-2) is a synthetic tripeptide with the amino acid sequence L-Glutamic acid–L-Aspartic acid–L-Arginine, developed by Professor Vladimir Khavinson and colleagues at the Saint Petersburg Institute of Bioregulation and Gerontology as part of the cytogen class of short peptide bioregulators, supplied by Nextday Peptides in lyophilized format for laboratory and analytical research applications. Originally isolated from brain cortex peptide extracts (Cortexin) rather than the pineal gland itself, Pinealon is studied as a research tool for investigating neuroprotective signaling, oxidative stress response, dendritic spine biology, and circadian rhythm-associated gene expression dynamics in controlled neural cell and preclinical experimental systems. For scientific research use only.
Compound Specifications
| Compound Name | Pinealon / EDR Peptide / Glu-Asp-Arg / T-33 Peptide |
| Peptide Sequence | Glu-Asp-Arg (L-Glutamic acid–L-Aspartic acid–L-Arginine) |
| Single Letter Code | EDR |
| Amino Acids | 3 (Tripeptide) |
| Classification | Cytogen class synthetic peptide bioregulator — CNS/pineal tissue targeting |
| Molecular Formula | C₁₅H₂₆N₆O₈ |
| Molecular Weight | 418.40 g/mol |
| CAS Number | 175175-23-2 |
| Form | Lyophilized powder |
| Appearance | White to off-white powder (hygroscopic) |
| Purity | ≥99% (HPLC verified) |
| Solubility | Soluble in sterile water and buffered aqueous solutions |
| Storage | -20°C desiccated lyophilized; 2–8°C after reconstitution |
| Synonyms | EDR, EDR peptide, T-33 peptide, Glu-Asp-Arg, Pineal tripeptide |
Why Research Laboratories Select Pinealon
Pinealon is the primary synthetic research tool for studying the Glu-Asp-Arg (EDR) tripeptide sequence — the defined active sequence from the Khavinson bioregulator program targeting CNS and pineal-associated tissue biology. Its small tripeptide size (MW 418 Da) provides notable membrane permeability and reported oral bioavailability compared to larger peptides, while its mixed charge distribution (two acidic residues and one basic residue) supports interaction with regulatory DNA sequences proposed in the Khavinson epigenetic bioregulator hypothesis.
- Cytogen class tripeptide — defined Glu-Asp-Arg sequence from Khavinson bioregulator research program
- CNS and pineal tissue targeting — studied for neuroprotective signaling in neural cell research models
- Dendritic spine biology — EDR restored neuronal dendritic spine number in in-vitro Alzheimer’s disease models (2017)
- 5xFAD transgenic mouse model — EDR prevented hippocampal dendritic spine loss in Alzheimer’s model (2021)
- Oxidative stress research — studied for ROS marker modulation in neural cell oxidative stress experimental systems
- Circadian/melatonin axis — studied in pineal-associated gene expression and melatonin pathway research models
- Small tripeptide MW — membrane permeability and reported oral bioavailability studied in preclinical models
- Studied alongside Epitalon — complementary Khavinson bioregulator program research tools
Research Background
Pinealon was developed by Professor Vladimir Khavinson’s group at the Saint Petersburg Institute of Bioregulation and Gerontology. Despite its name, Pinealon (EDR) was isolated from bovine brain cortex extract (Cortexin) rather than from pineal tissue. Khavinson et al. have published extensively on the cytogen class of short peptide bioregulators throughout the 2000s and 2010s. In 2017 studies examining EDR and the related tripeptide KED restored neuronal dendritic spine numbers in in-vitro Alzheimer’s disease models. A 2021 in-vivo study in 5xFAD transgenic Alzheimer’s mice demonstrated that EDR prevented hippocampal dendritic spine loss. Published literature is primarily from the St. Petersburg Institute with limited independent Western replication. All information provided here is for educational and reference purposes only and does not constitute medical or clinical guidance.
Reference sources: PubChem — Pinealon | Khavinson et al. (2002) — Neuro Endocrinol Lett
Shipping & Fulfillment
- Ships from U.S. warehouses — Florida, North Carolina, and California
- Overnight and 2-day shipping available at checkout
- Same-day processing on orders placed before 3:30 PM ET
- Discreet packaging with full tracking provided
- Bulk research orders welcome — contact us for volume pricing
Storage & Handling
- Store lyophilized powder desiccated at -20°C away from light and moisture — compound is hygroscopic
- After reconstitution store at 2–8°C and use within 14 days
- Avoid repeated freeze-thaw cycles to maintain peptide integrity
- Handle using appropriate laboratory safety protocols
- Keep containers tightly sealed when not in use
Frequently Asked Questions
What is Pinealon?
Pinealon (EDR, CAS 175175-23-2) is a synthetic tripeptide with the sequence Glu-Asp-Arg (L-Glutamic acid–L-Aspartic acid–L-Arginine). Developed by Professor Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology, it belongs to the cytogen class of short peptide bioregulators targeting CNS and pineal-associated tissue biology. Supplied strictly for scientific, analytical, and in-vitro laboratory research use only.
Why is Pinealon called a “pineal” peptide if it was isolated from brain cortex?
Pinealon was named for its proposed tissue targeting affinity toward pineal gland and CNS tissue, not its isolation source. It was actually isolated from bovine brain cortex extract (Cortexin) by Khavinson’s group. The naming convention in the Khavinson bioregulator program refers to the target tissue specificity proposed for each peptide, not the extraction source.
What is the cytogen class of peptide bioregulators?
Cytogens are synthetic reproductions of short peptide sequences (typically 2–7 amino acids) originally identified in organ-specific tissue extracts by the Khavinson research program. Each cytogen is proposed to target a specific tissue type through direct nuclear penetration and interaction with regulatory DNA sequences — a proposed epigenetic bioregulation mechanism. Pinealon (EDR) targets CNS/pineal tissue; Epitalon (AEDG) targets pineal telomerase biology; Thymalin (Thymulin) targets thymic immune tissue.
How does Pinealon differ from Epitalon?
Epitalon (AEDG, Ala-Glu-Asp-Gly) is a tetrapeptide primarily studied for telomerase activation and telomere biology in the Khavinson bioregulator framework. Pinealon (EDR, Glu-Asp-Arg) is a tripeptide primarily studied for neuroprotective signaling, dendritic spine biology, and circadian gene expression research. Both belong to the Khavinson cytogen class but target different molecular pathways.
What purity is your Pinealon?
Every batch is independently verified to ≥99% HPLC purity. A Certificate of Analysis is available for each lot.
How fast does Nextday Peptides ship?
We ship from U.S. warehouses in Florida, North Carolina, and California. Overnight and 2-day shipping options are available. Orders placed before 3:30 PM ET are processed same day.
Are bulk orders available?
Yes. We accommodate bulk research orders. Contact us directly for volume pricing and availability.
Is this product approved for medical use?
No. This product is for laboratory research use only. It is not approved for human or veterinary use, and is not intended for diagnostic, therapeutic, or clinical applications of any kind.
What other compounds does Nextday Peptides carry?
We also carry Epitalon, DSIP, Thymosin Alpha-1, and Semax. View our full research compounds catalog.
For Research Use Only — Not for human or veterinary consumption • Not evaluated by the FDA • Supplied by Nextday Peptides for controlled in-vitro laboratory research use only
