Epitalon (Epithalon)

Epitalon Research Peptide (Epithalon / AEDG Tetrapeptide)
Lyophilized Format • ≥99% HPLC Purity • Ships in 1–2 Business Days • U.S. Warehouses

Epitalon (Epithalon, CAS 307297-39-8) is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly, originally identified as the putative active component of bovine pineal gland extract epithalamin, supplied by Nextday Peptides in lyophilized format for laboratory and analytical research applications. Developed by Vladimir Khavinson’s group at the St. Petersburg Institute of Bioregulation and Gerontology, Epitalon has been studied as a research tool for investigating telomerase enzyme activity, hTERT transcriptional regulation, telomere biology, and chromatin state dynamics in controlled in-vitro experimental systems. Each vial is independently verified to ≥99% HPLC purity with a Certificate of Analysis available on request. For scientific research use only.

Compound Specifications

Why Research Laboratories Select Epitalon

Epitalon is one of the most studied synthetic tetrapeptides in current telomere biology and cellular aging research. As a small chemically defined four amino acid peptide, it serves as a useful tool compound for laboratories investigating telomerase enzyme activity assays, hTERT transcriptional regulation, chromatin state markers, and telomere dynamics in controlled cell culture experimental systems. Its small size makes it amenable to standard analytical frameworks including sequence verification, purity assessment, and compatibility with diverse assay environments.

• Synthetic tetrapeptide (Ala-Glu-Asp-Gly) — small, chemically defined, amenable to standard analytical frameworks
• Studied for hTERT upregulation in human fibroblast cell culture models — published in peer-reviewed literature
• Research tool for telomerase enzyme activity assays, TRAP assays, and telomere length measurement studies
• Studied in bovine cumulus cell and cumulus-oocyte complex models for telomerase activity — published in PMC
• Examined for DNA binding interactions with specific ATTTG sequence motifs in structural biology research
• Referenced in over 100 publications primarily from the St. Petersburg Institute of Bioregulation and Gerontology
• Lyophilized format ensures stability and reproducibility across experimental runs
• Batch and lot identifiers on all labeling for full laboratory documentation compliance

Research Background

Epitalon was developed by Vladimir Khavinson’s group at the St. Petersburg Institute of Bioregulation and Gerontology as the synthetic equivalent of the active component of bovine pineal gland extract epithalamin. Khavinson et al. published in-vitro findings on hTERT upregulation in human somatic fibroblast cell cultures. Anisimov et al. (2002) published preclinical findings in Cancer Letters examining Epitalon in chemically induced carcinogenesis rodent models. Subsequent publications have examined telomerase activity in bovine cumulus cells and DNA binding interactions. An overview review was published in PMC in 2025 (PMC11943447). All information provided here is for educational and reference purposes only and does not constitute medical or clinical guidance.

Reference sources: PubChem — Epitalon (CID 219042) | NIH PMC — Epitalon Overview (2025) | Wikipedia — Epitalon

⚠️ Regulatory Notice

The FDA classified Epitalon (Epitalon) as a Category 2 bulk drug substance under Section 503A guidance issued September 29, 2023, confirmed in a September 2024 update. Category 2 classification restricts licensed compounding pharmacies in the United States from preparing Epitalon for human administration. Epitalon is also listed on the World Anti-Doping Agency (WADA) prohibited list. This product is supplied strictly for controlled in-vitro laboratory research use only by qualified research professionals. It is not for human or veterinary use under any circumstances.

Shipping & Fulfillment

• Ships from U.S. warehouses — Florida, North Carolina, and California
• Overnight and 2-day shipping available at checkout
• Same-day processing on orders placed before 3:30 PM ET
• Discreet packaging with full tracking provided
• Bulk research orders welcome — contact us for volume pricing

Storage & Handling

• Store lyophilized peptide at -20°C away from light and moisture
• After reconstitution store at 2–8°C and use within 7 days
• For long-term storage keep desiccated below -18°C
• Avoid repeated freeze-thaw cycles to maintain peptide integrity
• Handle using appropriate laboratory safety protocols
• Keep containers sealed when not in use

Frequently Asked Questions

For Research Use Only — Not for human or veterinary consumption • Not evaluated by the FDA • FDA Category 2 bulk drug substance — supplied by Nextday Peptides for controlled in-vitro laboratory research use only