Thymosin Alpha-1 Research Peptide (Tα1)
Lyophilized Format • ≥99% HPLC Purity • Ships in 1–2 Business Days • U.S. Warehouses
Thymosin Alpha-1 (Tα1, Thymalfasin, CAS 62304-98-7) is a naturally occurring N-terminally acetylated 28 amino acid thymic peptide first isolated from calf thymus by Allan Goldstein’s laboratory at George Washington University in 1977, supplied by Nextday Peptides for laboratory and analytical research applications. Corresponding to an active fragment of the endogenous thymic hormone prothymosin-α, Thymosin Alpha-1 is one of the most extensively studied immunomodulatory peptides in current innate and adaptive immunity research. Each vial is independently verified to ≥99% HPLC purity with a Certificate of Analysis available on request. For scientific research use only.
Compound Specifications
| Compound Name | Thymosin Alpha-1 / Tα1 / Thymalfasin |
| Peptide Sequence | Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn |
| Sequence Code | Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN |
| Amino Acids | 28 — N-terminally acetylated |
| Origin | Active fragment of prothymosin-α (thymic hormone) |
| Molecular Formula | C₁₂₉H₂₁₅N₃₃O₅₅ |
| Molecular Weight | 3,108.32 g/mol |
| PubChem CID | 16130571 |
| CAS Number | 62304-98-7 |
| Form | Lyophilized powder |
| Appearance | White to off-white powder |
| Purity | ≥99% (HPLC verified) |
| Storage | ≤-20°C lyophilized; 2–8°C after reconstitution — use within 7 days |
| Synonyms | Tα1, Thymalfasin, Zadaxin sequence, Thymosin α1 |
Why Research Laboratories Select Thymosin Alpha-1
Thymosin Alpha-1 is one of the most unique immunomodulatory research peptides available — it simultaneously activates two distinct Toll-like receptor pathways (TLR2 on myeloid dendritic cells and TLR9 on plasmacytoid dendritic cells), providing a broad-spectrum innate immunity research tool that most single-receptor immunomodulatory compounds cannot replicate. Its dual TLR activation profile, combined with downstream effects on adaptive T-cell differentiation, makes it an essential reference compound for laboratories investigating immune signaling cascades, dendritic cell maturation biology, and T-cell polarization research models.
- 28 amino acid N-terminally acetylated thymic peptide — first isolated in 1977 by Goldstein et al.
- Dual TLR agonist — activates TLR2 on myeloid dendritic cells (NF-κB/p38 MAPK) and TLR9 on plasmacytoid dendritic cells (IRF3/IRF7 → IFN-α/IFN-γ)
- Studied in innate and adaptive immunity research — dendritic cell maturation, T-cell differentiation, NK cell cytotoxicity, and Treg generation
- Synthetic equivalent of the natural thymic peptide — identical amino acid sequence to thymalfasin (Zadaxin)
- Approved as thymalfasin (Zadaxin) in 35+ countries — one of the most clinically studied research peptides with extensive published literature
- Referenced in peer-reviewed literature including Blood, Annals of the New York Academy of Sciences, and Journal of Immunology
- Lyophilized format ensures stability and reproducibility across experimental runs
- Batch and lot identifiers on all labeling for full laboratory documentation compliance
Research Background
Thymosin Alpha-1 was first isolated from calf thymus by Goldstein et al. in 1977 and its sequence characterized from prothymosin-α in the early 1980s. Romani et al. (2006) published landmark findings in Blood demonstrating that Tα1 activates dendritic cell tryptophan catabolism through TLR2 and TLR9 signaling. The synthetic form, thymalfasin (Zadaxin), developed by SciClone Pharmaceuticals, is approved in 35+ countries for chronic hepatitis B, chronic hepatitis C, and as an immune adjuvant in cancer and vaccine settings. Naylor and Goldstein (2006) published a comprehensive review in Current Immunology Reviews on thymosin peptide roles in immune regulation. All information provided here is for educational and reference purposes only and does not constitute medical or clinical guidance.
Reference sources: PubChem — Thymosin Alpha-1 (CID 16130571) | Romani et al. (2006) — Blood
Shipping & Fulfillment
- Ships from U.S. warehouses — Florida, North Carolina, and California
- Overnight and 2-day shipping available at checkout
- Same-day processing on orders placed before 3:30 PM ET
- Discreet packaging with full tracking provided
- Bulk research orders welcome — contact us for volume pricing
Storage & Handling
- Store lyophilized peptide at -20°C or below away from light and moisture
- After reconstitution store at 2–8°C and use within 7 days
- Aliquot into single-use portions after reconstitution to avoid repeated freeze-thaw cycles
- Avoid repeated freeze-thaw cycles to maintain peptide integrity
- Handle using appropriate laboratory safety protocols
- Keep containers sealed when not in use
Frequently Asked Questions
What is Thymosin Alpha-1?
Thymosin Alpha-1 (Tα1, CAS 62304-98-7) is a naturally occurring N-terminally acetylated 28 amino acid thymic peptide first isolated by Goldstein et al. in 1977. It corresponds to an active fragment of prothymosin-α and is studied extensively in innate and adaptive immunity research. Supplied strictly for scientific, analytical, and in-vitro laboratory research use only.
What makes Thymosin Alpha-1 unique among immunomodulatory research peptides?
Most immunomodulatory compounds target a single receptor pathway. Thymosin Alpha-1 simultaneously activates two Toll-like receptors — TLR2 on myeloid dendritic cells (triggering NF-κB/p38 MAPK signaling and Th1 cytokine production) and TLR9 on plasmacytoid dendritic cells (triggering IRF3/IRF7 → IFN-α/IFN-γ). This dual TLR activation profile makes it a uniquely comprehensive immunomodulatory research tool.
What is thymalfasin and how does it relate to Thymosin Alpha-1?
Thymalfasin is the International Nonproprietary Name (INN) for the synthetic form of Thymosin Alpha-1. Marketed as Zadaxin by SciClone Pharmaceuticals, thymalfasin has an identical amino acid sequence to naturally occurring Thymosin Alpha-1 and is approved in 35+ countries. Research-grade Thymosin Alpha-1 supplied by Nextday Peptides has the same amino acid sequence and is supplied for laboratory research use only — it is not equivalent to any approved drug product.
How does Thymosin Alpha-1 differ from Thymosin Beta-4 (TB-500)?
Thymosin Alpha-1 and Thymosin Beta-4 are both thymic peptides but have completely different sequences, molecular targets, and research applications. Thymosin Alpha-1 (28 AA) targets TLR2 and TLR9 in immune signaling research. Thymosin Beta-4 / TB-500 (43 AA) targets actin-binding pathways and cytoskeletal biology research. They are studied in entirely separate research contexts.
What purity is your Thymosin Alpha-1?
Every batch is independently verified to ≥99% HPLC purity. A Certificate of Analysis is available for each lot.
How fast does Nextday Peptides ship?
We ship from U.S. warehouses in Florida, North Carolina, and California. Overnight and 2-day shipping options are available. Orders placed before 3:30 PM ET are processed same day.
Are bulk orders available?
Yes. We accommodate bulk research orders. Contact us directly for volume pricing and availability.
Is this product approved for medical use?
No. This research-grade product is for laboratory research use only and is not equivalent to any approved drug product. It is not approved for human or veterinary use, and is not intended for diagnostic, therapeutic, or clinical applications.
What other compounds does Nextday Peptides carry?
We stock a full range of research peptides including TB-500 (Thymosin Beta-4), BPC-157, LL-37, and MOTS-C. View our full research compounds catalog.
For Research Use Only — Not for human or veterinary consumption • Not evaluated by the FDA • Supplied by Nextday Peptides for laboratory research applications only
