KPV Research Peptide (Lys-Pro-Val)
Lyophilized Format • ≥99% HPLC Purity • Ships in 1–2 Business Days • U.S. Warehouses
KPV peptide (Lys-Pro-Val) is a synthetic tripeptide fragment derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone (α-MSH, positions 11-13), supplied by Nextday Peptides for laboratory and analytical research applications. As one of the most studied tripeptide fragments in inflammatory signaling research, KPV is valued for its ability to enter cells via the PepT1 oligopeptide transporter in experimental models. Each vial is independently verified to ≥99% HPLC purity with a Certificate of Analysis available on request. For scientific research use only.
Compound Specifications
| Compound Name | KPV / Lys-Pro-Val |
| Peptide Sequence | Lys-Pro-Val |
| Amino Acids | 3 (Tripeptide) |
| Origin | C-terminal fragment of α-MSH (positions 11-13) |
| Molecular Formula | C₁₇H₃₁N₅O₄ |
| Molecular Weight | 369.46 g/mol |
| Form | Lyophilized powder |
| Appearance | White to off-white powder |
| Purity | ≥99% (HPLC verified) |
| Storage | -20°C lyophilized; 2–8°C after reconstitution |
| CAS Number | 67727-97-3 |
Why Research Laboratories Select KPV
KPV is among the most studied C-terminal α-MSH fragment tripeptides in current inflammatory signaling and epithelial biology research. Its small three amino acid structure allows direct cellular uptake via the PepT1 oligopeptide transporter in experimental models, making it a useful tool for laboratories investigating NF-κB pathway modulation, MAPK signaling, and epithelial barrier biology without full-length melanocortin receptor activation.
- Three amino acid synthetic tripeptide — Lys-Pro-Val sequence derived from α-MSH positions 11-13
- Enters cells via PepT1 oligopeptide transporter in experimental models — studied at nanomolar concentrations
- Investigated for NF-κB nuclear translocation inhibition in intestinal epithelial cell models
- Studied in the context of ERK1/2, JNK, and p38 MAPK signaling in laboratory research
- Referenced in peer-reviewed literature on inflammatory signaling and epithelial barrier research
- Lyophilized format ensures stability and reproducibility across experimental runs
- Batch and lot identifiers on all labeling for full laboratory documentation compliance
Research Background
KPV (Lys-Pro-Val) has been referenced in scientific literature as the C-terminal tripeptide fragment of α-MSH since early studies on melanocortin peptide fragments. Preclinical studies have examined its cellular uptake mechanisms via the PepT1 transporter, NF-κB pathway interactions in intestinal epithelial cell models, and MAPK signaling modulation. Zhao et al. (2022) published findings on KPV-containing hydrogel formulations in Acta Biomaterialia. All information provided here is for educational and reference purposes only and does not constitute medical or clinical guidance.
Reference sources: PubChem — KPV
Shipping & Fulfillment
- Ships from U.S. warehouses — Florida, North Carolina, and California
- Overnight and 2-day shipping available at checkout
- Same-day processing on orders placed before cutoff
- Discreet packaging with full tracking provided
- Bulk research orders welcome — contact us for volume pricing
Storage & Handling
- Store lyophilized peptide at -20°C away from light and moisture
- After reconstitution, store at 2–8°C and use promptly
- Avoid repeated freeze-thaw cycles to maintain integrity
- Handle using appropriate laboratory safety protocols
- Keep containers sealed when not in use
Frequently Asked Questions
What is KPV peptide?
KPV (Lys-Pro-Val) is a synthetic tripeptide fragment derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone (α-MSH). It is supplied strictly for scientific, analytical, and in-vitro laboratory research use only.
How does KPV enter cells in experimental models?
In laboratory research models, KPV has been studied for its uptake via the PepT1 oligopeptide transporter with high affinity. Once inside cells in experimental systems, it has been examined for interactions with NF-κB pathway components and MAPK signaling cascades.
How does KPV relate to alpha-MSH?
KPV represents positions 11-13 of the alpha-MSH peptide sequence — the C-terminal tripeptide fragment. Research has examined whether this fragment reproduces aspects of α-MSH’s signaling properties in experimental systems through mechanisms that may be independent of full-length melanocortin receptor activation.
What purity is your KPV?
Every batch is independently verified to ≥99% HPLC purity. A Certificate of Analysis is available for each lot.
How fast does Nextday Peptides ship?
We ship from U.S. warehouses in Florida, North Carolina, and California. Overnight and 2-day shipping options are available. Most orders process same day.
Are bulk orders available?
Yes. We accommodate bulk research orders. Contact us directly for volume pricing and availability.
Is this product approved for medical use?
No. This product is for laboratory research use only. It is not approved for human or veterinary use, and is not intended for diagnostic, therapeutic, or clinical applications.
What other compounds does Nextday Peptides carry?
We stock a full range of research peptides including BPC-157, TB-500, Retatrutide GLP-3, and MOTS-C. View our full research compounds catalog.
For Research Use Only — Not for human or veterinary consumption • Not evaluated by the FDA • Supplied by Nextday Peptides for laboratory research applications only
