Gonadorelin Acetate Research Peptide (GnRH / LHRH Acetate Salt)
Acetate Salt Form • Lyophilized Format • ≥99% HPLC Purity • Ships in 1–2 Business Days • U.S. Warehouses
Gonadorelin Acetate (GnRH Acetate, LHRH Acetate, CAS 71447-49-9) is the acetate salt form of synthetic Gonadorelin — a decapeptide with the sequence pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂, identical in amino acid sequence to endogenous gonadotropin-releasing hormone produced by hypothalamic neurons — supplied by Nextday Peptides in lyophilized format for laboratory and analytical research applications. The acetate counterion is the most widely used pharmaceutical-grade salt form of Gonadorelin, offering excellent aqueous solubility and stability during lyophilization. As the primary hypothalamic regulator of the pituitary-gonadal axis, Gonadorelin Acetate activates GnRH receptors (GnRHR) on anterior pituitary gonadotroph cells via Gq/11-mediated phospholipase C signaling, making it an essential reference compound for HPG axis biology, GnRHR pharmacology, and gonadotropin signaling research. Each vial is independently verified to ≥99% HPLC purity with a Certificate of Analysis available on request. For scientific research use only.
Compound Specifications
| Compound Name | Gonadorelin Acetate / GnRH Acetate / LHRH Acetate |
| Peptide Sequence | pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂ |
| Amino Acids | 10 (Decapeptide) — N-terminal pyroglutamate, C-terminal amide |
| Salt Form | Acetate salt (acetic acid counterion) |
| Receptor Target | GnRHR (GnRH Receptor) — class A GPCR on pituitary gonadotrophs |
| Molecular Formula (free base) | C₅₅H₇₅N₁₇O₁₃ |
| Molecular Weight (free base) | 1,182.31 g/mol |
| PubChem CID | 638793 |
| CAS Number | 71447-49-9 (acetate salt) |
| Form | Lyophilized powder |
| Appearance | White to off-white powder |
| Purity | ≥99% (HPLC verified) |
| Storage | -20°C lyophilized; 2–8°C after reconstitution (use within 14 days) |
| Synonyms | GnRH Acetate, LHRH Acetate, Luliberin Acetate, Gonadoliberin Acetate, GnRH-I Acetate |
Why Research Laboratories Select Gonadorelin Acetate
Gonadorelin Acetate is the most widely used pharmaceutical salt form of synthetic GnRH in laboratory research — the acetate counterion enhances aqueous solubility, lyophilization stability, and vial-to-vial consistency compared to other salt forms. As the foundational GnRHR reference compound, it enables precise investigation of hypothalamic-pituitary-gonadal axis signaling, GnRH receptor pharmacology, and comparative GnRH analog structure-activity relationships across all major GHRH research frameworks.
- Acetate salt form — most widely used pharmaceutical-grade GnRH salt for laboratory research applications
- Enhanced aqueous solubility vs free base — acetate counterion improves solution preparation consistency
- Endogenous GnRH sequence — identical to native hypothalamic decapeptide with N-terminal pyroglutamate and C-terminal amide
- GnRHR full agonist — activates Gq/11/PLC pathway triggering IP3/DAG/Ca²⁺ second messenger cascade in pituitary gonadotrophs
- MAPK/ERK downstream pathway — studied in LH and FSH subunit gene expression transcriptional regulation research
- Pulsatile versus continuous stimulation research — studied for GnRHR sensitization and desensitization dynamics
- FDA-approved pharmaceutical equivalent (Factrel) uses acetate salt — extensive published clinical literature for reference
- Lyophilized format ensures stability and reproducibility across experimental runs
Research Background
GnRH was first isolated and characterized by Andrew Schally and Roger Guillemin — work for which they shared the Nobel Prize in Physiology or Medicine in 1977. The acetate salt form became the standard for pharmaceutical and research-grade GnRH production due to its superior stability and solubility properties. Gonadorelin Acetate has been studied in thousands of published preclinical and clinical research papers across reproductive biology, endocrinology, and neuroendocrinology. Research-grade Gonadorelin Acetate supplied by Nextday Peptides is not equivalent to any approved pharmaceutical formulation. All information provided here is for educational and reference purposes only and does not constitute medical or clinical guidance.
Reference sources: PubChem — Gonadorelin (CID 638793) | NIH StatPearls — Gonadorelin
Shipping & Fulfillment
- Ships from U.S. warehouses — Florida, North Carolina, and California
- Overnight and 2-day shipping available at checkout
- Same-day processing on orders placed before 3:30 PM ET
- Discreet packaging with full tracking provided
- Bulk research orders welcome — contact us for volume pricing
Storage & Handling
- Store lyophilized peptide desiccated at -20°C away from light and moisture
- After reconstitution store at 2–8°C and use within 14 days
- Reconstitute in sterile 18MΩ water at ≥100 µg/mL — can then be further diluted in aqueous buffers
- Avoid vigorous agitation during and after reconstitution to prevent aggregation
- Avoid repeated freeze-thaw cycles to maintain peptide integrity
- Handle using appropriate laboratory safety protocols
Frequently Asked Questions
What is Gonadorelin Acetate?
Gonadorelin Acetate (GnRH Acetate, CAS 71447-49-9) is the acetate salt form of synthetic Gonadorelin — a decapeptide identical in sequence to endogenous gonadotropin-releasing hormone. The acetate counterion enhances aqueous solubility and lyophilization stability. It activates GnRH receptors on pituitary gonadotrophs triggering LH and FSH signaling cascades. Supplied strictly for scientific, analytical, and in-vitro laboratory research use only.
What is the difference between Gonadorelin Acetate and Gonadorelin free base?
Both contain the identical pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂ amino acid sequence. Gonadorelin Acetate (CAS 71447-49-9) carries an acetic acid counterion that enhances aqueous solubility and lyophilization stability — making it the preferred form for most laboratory research protocols and the salt form used in pharmaceutical-grade Gonadorelin preparations. Gonadorelin free base (CAS 33515-09-2) is preferred when precise counterion-free concentration calculations are required.
How does Gonadorelin Acetate activate the HPG axis in research models?
In experimental models Gonadorelin Acetate binds GnRHR — a class A GPCR on anterior pituitary gonadotroph cells — triggering Gq/11-mediated phospholipase C activation. This generates IP3 and DAG second messengers, mobilizes intracellular calcium, and activates protein kinase C and MAPK/ERK cascades that regulate transcriptional expression of LH and FSH subunit genes and their secretory machinery in gonadotroph cell research systems.
How does Gonadorelin Acetate relate to Kisspeptin-10 in HPG axis research?
Kisspeptin-10 acts upstream — kisspeptin neurons activate GnRH neurons via KISS1R/GPR54 signaling, stimulating GnRH (Gonadorelin) release from hypothalamic neurons. Gonadorelin then acts on pituitary gonadotrophs. Laboratories studying the complete HPG signaling cascade use Kisspeptin-10 and Gonadorelin Acetate as complementary research tools covering different tiers of the axis.
What purity is your Gonadorelin Acetate?
Every batch is independently verified to ≥99% HPLC purity. A Certificate of Analysis is available for each lot.
How fast does Nextday Peptides ship?
We ship from U.S. warehouses in Florida, North Carolina, and California. Overnight and 2-day shipping options are available. Orders placed before 3:30 PM ET are processed same day.
Are bulk orders available?
Yes. We accommodate bulk research orders. Contact us directly for volume pricing and availability.
Is this product approved for medical use?
Research-grade Gonadorelin Acetate is not equivalent to any approved pharmaceutical formulation. It is for laboratory research use only and is not intended for diagnostic, therapeutic, or clinical applications.
What other compounds does Nextday Peptides carry?
We also carry Gonadorelin (free base), Kisspeptin-10, Sermorelin, and Ipamorelin. View our full research compounds catalog.
For Research Use Only — Not for human or veterinary consumption • Not equivalent to any approved drug product • Supplied by Nextday Peptides for controlled in-vitro laboratory research use only
