FOXO4 (FOXO4-DRI)
Lyophilized powder • ≥99% HPLC Purity • Ships from U.S. Facilities • Research Use Only
FOXO4-DRI (CAS 2460055-10-9) is a cell-permeable D-retro-inverso (DRI) peptide antagonist of the FOXO4-p53 protein-protein interaction — the first synthetic senolytic peptide designed to selectively induce apoptosis in senescent cells by disrupting the nuclear retention of p53 by FOXO4 — supplied by Nextday Peptides in lyophilized format for laboratory and analytical research applications. The DRI modification — D-amino acid retro-inverso sequence — confers proteolytic resistance while preserving the binding interface geometry required for FOXO4-p53 interaction disruption. Originally characterized by Baar et al. (2017) in Cell, FOXO4-DRI is the primary research tool for investigating FOXO4/p53-dependent senescent cell apoptosis biology in controlled cell culture experimental systems. For scientific research use only.
Compound Specifications
| Compound Name | FOXO4-DRI / FOXO4 D-Retro-Inverso Peptide / FOXO4/p53 Antagonist |
|---|---|
| Molecular Formula | C₂₂₈H₃₈₈N₈₆O₆₄ |
| Molecular Weight | 5,358.06 g/mol |
| CAS Number | 2460055-10-9 |
| Form | Lyophilized powder |
| Appearance | White to off-white powder |
| Purity | ≥99% (HPLC verified) |
| Storage | -20°C lyophilized; 2–8°C after reconstitution — aliquot to avoid freeze-thaw |
| Classification | Cell-permeable D-retro-inverso senolytic peptide |
| Mechanism | FOXO4-p53 protein-protein interaction antagonist → p53 nuclear exclusion → mitochondrial apoptosis in senescent cells |
| Primary Target | FOXO4/p53 interaction interface |
| Synonyms | FOXO4-DRI, FOXO4 DRI peptide, Fork head box O4 D-Retro-Inverso |
| Intended Use | Laboratory / analytical / scientific research only |
Research Background
In controlled laboratory settings, investigators study FOXO4 (FOXO4-DRI) as a defined research material with characterized identity specifications suitable for analytical workflows. Common research synonyms / identifiers: FOXO4-DRI / FOXO4 D-Retro-Inverso Peptide / FOXO4/p53 Antagonist. Published literature and institutional protocols should be consulted by qualified personnel. Nextday Peptides does not provide experimental protocols for human use.
Storage & Handling
-20°C lyophilized; 2–8°C after reconstitution — aliquot to avoid freeze-thaw
- Use appropriate PPE and laboratory safe-handling practices.
- Reconstitute only with solvents suitable for your research method (e.g., sterile water, bacteriostatic water, or other protocol-defined vehicles).
- Do not use if packaging is compromised; contact support for lot documentation questions.
- Dispose of materials according to institutional chemical waste rules.
Shipping & Fulfillment
Orders are processed from U.S. facilities. Most in-stock research materials ship within 1–2 business days. Overnight options may be available where eligibility and destination allow. Packaging is selected to protect laboratory materials during transit.
Research Use Only
All products offered by Nextday Peptides are intended strictly for laboratory, analytical, and scientific research use only. They are not for human or veterinary consumption, clinical use, diagnostic use, or household use. Nothing on this page is medical advice. Resale for unlicensed or non-research purposes is prohibited. By purchasing, the buyer confirms they are a qualified research end-user and will handle materials in accordance with applicable laws and laboratory safety practices.
Frequently Asked Questions
Is FOXO4 (FOXO4-DRI) for human use?
No. This material is sold strictly for laboratory and scientific research. It is not a drug, supplement, or cosmetic, and is not for human or animal consumption.
Do you provide a Certificate of Analysis?
Yes. Lot-specific Certificates of Analysis (including HPLC purity where applicable) are available upon request for research documentation.
How should laboratories store this material?
Follow the storage guidance in the product specifications and your institutional SOPs. Lyophilized peptides are typically stored frozen, protected from light and moisture.
Who may purchase research materials?
Purchasers should be qualified research end-users who will use materials only in compliant laboratory contexts. Nextday Peptides reserves the right to refuse orders that fall outside research use.
