ARA-290 (Cibinetide)
Lyophilized powder • ≥99% HPLC Purity • Ships from U.S. Facilities • Research Use Only
ARA-290 (Cibinetide, PHBSP — Pyroglutamate Helix B Surface Peptide, CAS 1208243-50-8) is a synthetic 11 amino acid non-erythropoietic peptide derived from the helix B surface domain of erythropoietin (EPO), developed by Dr. Michael Brines and colleagues at Araim Pharmaceuticals to selectively activate the innate repair receptor (IRR) without engaging the classical erythropoietic EPOR homodimer, supplied by Nextday Peptides in lyophilized format for laboratory and analytical research applications. The IRR is a heterodimeric complex of the EPO receptor (EPOR) and the beta-common receptor (CD131, βCR) that is selectively upregulated in injured and inflamed tissue while largely absent in healthy uninjured cells. ARA-290 has received FDA Orphan Drug designation for sarcoidosis-associated neuropathy and has progressed through Phase 2 human clinical trials. For scientific research use only.
Compound Specifications
| Compound Name | ARA-290 / Cibinetide / PHBSP / Pyroglutamate Helix B Surface Peptide |
|---|---|
| Amino Acids | 11 — N-terminal pyroglutamate |
| Receptor Target | IRR — Innate Repair Receptor (EPOR/CD131 heterodimer) |
| CAS Number | 1208243-50-8 |
| Form | Lyophilized powder |
| Appearance | White to off-white powder |
| Purity | ≥99% (HPLC verified) |
| Storage | -20°C lyophilized; 2–8°C after reconstitution |
| Peptide Sequence | pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser |
| Origin | Helix B surface domain of erythropoietin (EPO) — non-erythropoietic region |
| Erythropoietic Activity | None — does not stimulate EPOR homodimer or red blood cell production |
| Synonyms | Cibinetide, PHBSP, ARA290, Pyroglutamate HBSP, pGlu-HBSP |
| Intended Use | Laboratory / analytical / scientific research only |
Research Background
In controlled laboratory settings, investigators study ARA-290 (Cibinetide) as a defined research material with characterized identity specifications suitable for analytical workflows. Reported sequence length in literature and product documentation: 11 — N-terminal pyroglutamate amino acids. Documented experimental target class: IRR — Innate Repair Receptor (EPOR/CD131 heterodimer). Common research synonyms / identifiers: ARA-290 / Cibinetide / PHBSP / Pyroglutamate Helix B Surface Peptide. Published literature and institutional protocols should be consulted by qualified personnel. Nextday Peptides does not provide experimental protocols for human use.
Storage & Handling
-20°C lyophilized; 2–8°C after reconstitution
- Use appropriate PPE and laboratory safe-handling practices.
- Reconstitute only with solvents suitable for your research method (e.g., sterile water, bacteriostatic water, or other protocol-defined vehicles).
- Do not use if packaging is compromised; contact support for lot documentation questions.
- Dispose of materials according to institutional chemical waste rules.
Shipping & Fulfillment
Orders are processed from U.S. facilities. Most in-stock research materials ship within 1–2 business days. Overnight options may be available where eligibility and destination allow. Packaging is selected to protect laboratory materials during transit.
Research Use Only
All products offered by Nextday Peptides are intended strictly for laboratory, analytical, and scientific research use only. They are not for human or veterinary consumption, clinical use, diagnostic use, or household use. Nothing on this page is medical advice. Resale for unlicensed or non-research purposes is prohibited. By purchasing, the buyer confirms they are a qualified research end-user and will handle materials in accordance with applicable laws and laboratory safety practices.
Frequently Asked Questions
Is ARA-290 (Cibinetide) for human use?
No. This material is sold strictly for laboratory and scientific research. It is not a drug, supplement, or cosmetic, and is not for human or animal consumption.
Do you provide a Certificate of Analysis?
Yes. Lot-specific Certificates of Analysis (including HPLC purity where applicable) are available upon request for research documentation.
How should laboratories store this material?
Follow the storage guidance in the product specifications and your institutional SOPs. Lyophilized peptides are typically stored frozen, protected from light and moisture.
Who may purchase research materials?
Purchasers should be qualified research end-users who will use materials only in compliant laboratory contexts. Nextday Peptides reserves the right to refuse orders that fall outside research use.
ARA-290: laboratory research overview
Ara-290 (cibinetide) is supplied by Nextday Peptides as research-grade material for controlled laboratory, analytical, and scientific applications. Intended strictly for research use only — not for human or veterinary use. Certificate of Analysis (COA) available for laboratory intake records.
This material is also located under related phrasing such as ARA-290 peptide, alongside ARA-290.
Labeled for procurement and inventory alignment with literature nomenclature. No consumer, clinical, dosage, or therapeutic framing. Ships from U.S. facilities to qualified research buyers.
Related research terminology for this listing
- ARA-290 — laboratory identification and literature alignment
- ARA-290 peptide — laboratory identification and literature alignment
Research use only. Not for human consumption, clinical administration, diagnostic use, or veterinary use. No outcome or dosing claims are implied.
