Survodutide
Lyophilized powder • ≥99% HPLC Purity • Ships from U.S. Facilities • Research Use Only
Survodutide (BI 456906, CAS 2805997-46-8) is a synthetic 29 amino acid long-acting dual agonist of the glucagon receptor (GCGR) and glucagon-like peptide-1 receptor (GLP-1R), developed by Boehringer Ingelheim in partnership with Zealand Pharma, supplied by Nextday Peptides in lyophilized format for laboratory and analytical research applications. Structurally distinct from oxyntomodulin-based dual agonists — Survodutide is a glucagon analog rather than an oxyntomodulin analog — incorporating a non-coded amino acid residue (Ac4c, 1-Aminocyclobutane-1-carboxylic acid) at position 2 for DPP-IV resistance, and a C18 fatty diacid moiety via a hydrophilic linker at lysine-24 for albumin-mediated half-life extension. In CHO-K1 cell assays it demonstrates EC50 values of 0.52 nM at GCGR and 0.33 nM at GLP-1R. For scientific research use only.
Compound Specifications
| Compound Name | Survodutide / BI 456906 |
|---|---|
| Amino Acids | 29 |
| CAS Number | 2805997-46-8 |
| Form | Lyophilized powder |
| Appearance | White to off-white powder |
| Purity | ≥99% (HPLC verified) |
| Storage | -20°C lyophilized; 2–8°C after reconstitution |
| Classification | Glucagon-based dual GCGR/GLP-1R agonist — long-acting acylated peptide |
| Receptor Targets | GCGR (EC50 0.52 nM) + GLP-1R (EC50 0.33 nM) in CHO-K1 cells |
| Structural Basis | Glucagon analog (not oxyntomodulin) — distinct from Mazdutide and Retatrutide |
| Position 2 Modification | Ac4c (1-Aminocyclobutane-1-carboxylic acid) — DPP-IV resistance |
| Acylation | C18 fatty diacid via hydrophilic linker at Lys-24 — albumin binding, half-life extension |
| Intended Use | Laboratory / analytical / scientific research only |
Research Background
In controlled laboratory settings, investigators study Survodutide as a defined research material with characterized identity specifications suitable for analytical workflows. Reported sequence length in literature and product documentation: 29 amino acids. Common research synonyms / identifiers: Survodutide / BI 456906. Published literature and institutional protocols should be consulted by qualified personnel. Nextday Peptides does not provide experimental protocols for human use.
Storage & Handling
-20°C lyophilized; 2–8°C after reconstitution
- Use appropriate PPE and laboratory safe-handling practices.
- Reconstitute only with solvents suitable for your research method (e.g., sterile water, bacteriostatic water, or other protocol-defined vehicles).
- Do not use if packaging is compromised; contact support for lot documentation questions.
- Dispose of materials according to institutional chemical waste rules.
Shipping & Fulfillment
Orders are processed from U.S. facilities. Most in-stock research materials ship within 1–2 business days. Overnight options may be available where eligibility and destination allow. Packaging is selected to protect laboratory materials during transit.
Research Use Only
All products offered by Nextday Peptides are intended strictly for laboratory, analytical, and scientific research use only. They are not for human or veterinary consumption, clinical use, diagnostic use, or household use. Nothing on this page is medical advice. Resale for unlicensed or non-research purposes is prohibited. By purchasing, the buyer confirms they are a qualified research end-user and will handle materials in accordance with applicable laws and laboratory safety practices.
Frequently Asked Questions
Is Survodutide for human use?
No. This material is sold strictly for laboratory and scientific research. It is not a drug, supplement, or cosmetic, and is not for human or animal consumption.
Do you provide a Certificate of Analysis?
Yes. Lot-specific Certificates of Analysis (including HPLC purity where applicable) are available upon request for research documentation.
How should laboratories store this material?
Follow the storage guidance in the product specifications and your institutional SOPs. Lyophilized peptides are typically stored frozen, protected from light and moisture.
Who may purchase research materials?
Purchasers should be qualified research end-users who will use materials only in compliant laboratory contexts. Nextday Peptides reserves the right to refuse orders that fall outside research use.
